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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSP90AA2
All Species:
24.24
Human Site:
S252
Identified Species:
41.03
UniProt:
Q14568
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14568
NP_005339
343
39365
S252
K
E
K
E
E
K
E
S
K
D
K
P
E
I
E
Chimpanzee
Pan troglodytes
A5A6K9
733
84754
S252
K
E
K
E
E
K
E
S
E
D
K
P
E
I
E
Rhesus Macaque
Macaca mulatta
XP_001098426
696
80269
G530
Q
Q
L
K
E
F
D
G
K
S
L
V
S
V
T
Dog
Lupus familis
XP_848783
483
56243
S252
K
E
K
E
E
K
E
S
D
D
K
P
E
I
E
Cat
Felis silvestris
Mouse
Mus musculus
P07901
733
84769
S252
K
E
K
E
E
K
E
S
D
D
K
P
E
I
E
Rat
Rattus norvegicus
P82995
733
84796
S252
K
E
K
E
E
K
E
S
D
D
K
P
E
I
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512830
733
84847
T252
E
K
E
E
K
E
E
T
E
D
K
P
E
I
E
Chicken
Gallus gallus
P11501
728
84041
D250
E
K
E
E
K
T
E
D
K
P
E
I
E
D
V
Frog
Xenopus laevis
NP_001085598
729
84174
E251
K
D
E
P
K
D
E
E
K
P
E
I
E
D
V
Zebra Danio
Brachydanio rerio
Q90474
725
83300
G531
Q
Q
L
K
E
Y
D
G
K
N
L
V
S
V
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02828
717
81847
V402
K
V
I
R
K
N
L
V
K
K
T
M
E
L
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q18688
702
80265
V388
K
V
I
R
K
N
L
V
K
K
C
M
E
L
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P55737
699
80046
T516
G
K
K
L
V
S
A
T
K
E
G
L
K
L
D
Baker's Yeast
Sacchar. cerevisiae
P15108
705
80881
A534
E
E
T
D
E
E
K
A
E
R
E
K
E
I
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
45
39.6
67.6
N.A.
44.8
45
N.A.
42.9
40.5
39.3
36.9
N.A.
36.8
N.A.
34.1
N.A.
Protein Similarity:
100
45.5
44.4
68.9
N.A.
45.5
45.5
N.A.
44.7
43.1
42.7
43
N.A.
41.4
N.A.
41.3
N.A.
P-Site Identity:
100
93.3
13.3
93.3
N.A.
93.3
93.3
N.A.
53.3
26.6
26.6
13.3
N.A.
20
N.A.
20
N.A.
P-Site Similarity:
100
100
46.6
93.3
N.A.
93.3
93.3
N.A.
100
60
53.3
53.3
N.A.
33.3
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
35.4
31.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41.9
39.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
80
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
8
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% C
% Asp:
0
8
0
8
0
8
15
8
22
43
0
0
0
15
8
% D
% Glu:
22
43
22
50
58
15
58
8
22
8
22
0
79
0
43
% E
% Phe:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
0
0
0
0
0
15
0
0
8
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
15
0
0
0
0
0
0
0
0
15
0
50
15
% I
% Lys:
58
22
43
15
36
36
8
0
58
15
43
8
8
0
8
% K
% Leu:
0
0
15
8
0
0
15
0
0
0
15
8
0
22
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
15
0
0
0
% M
% Asn:
0
0
0
0
0
15
0
0
0
8
0
0
0
0
0
% N
% Pro:
0
0
0
8
0
0
0
0
0
15
0
43
0
0
0
% P
% Gln:
15
15
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
15
0
0
0
0
0
8
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
8
0
36
0
8
0
0
15
0
0
% S
% Thr:
0
0
8
0
0
8
0
15
0
0
8
0
0
0
15
% T
% Val:
0
15
0
0
8
0
0
15
0
0
0
15
0
15
15
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _