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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSP90AA2
All Species:
20.91
Human Site:
T176
Identified Species:
35.38
UniProt:
Q14568
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14568
NP_005339
343
39365
T176
S
F
T
V
R
T
D
T
G
E
R
M
G
R
G
Chimpanzee
Pan troglodytes
A5A6K9
733
84754
T176
S
F
T
V
R
T
D
T
G
E
P
M
G
R
G
Rhesus Macaque
Macaca mulatta
XP_001098426
696
80269
I441
S
K
N
L
K
L
G
I
H
E
D
S
T
N
R
Dog
Lupus familis
XP_848783
483
56243
T176
S
F
T
V
R
T
D
T
G
E
P
M
G
R
G
Cat
Felis silvestris
Mouse
Mus musculus
P07901
733
84769
T176
S
F
T
V
R
T
D
T
G
E
P
M
G
R
G
Rat
Rattus norvegicus
P82995
733
84796
T176
S
F
T
V
R
T
D
T
G
E
P
M
G
R
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512830
733
84847
T176
S
F
T
V
R
I
D
T
G
E
P
I
G
R
G
Chicken
Gallus gallus
P11501
728
84041
N175
S
F
T
V
R
L
D
N
G
E
P
L
G
R
G
Frog
Xenopus laevis
NP_001085598
729
84174
N177
S
F
T
V
R
V
D
N
S
E
P
L
G
R
G
Zebra Danio
Brachydanio rerio
Q90474
725
83300
G243
E
E
E
E
V
A
A
G
E
D
K
D
K
P
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02828
717
81847
E235
K
E
G
D
E
K
K
E
M
E
T
D
E
P
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q18688
702
80265
P205
H
S
Q
F
I
G
Y
P
I
K
L
V
V
E
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P55737
699
80046
I420
S
K
N
L
K
L
G
I
H
E
D
S
Q
N
R
Baker's Yeast
Sacchar. cerevisiae
P15108
705
80881
D234
E
E
K
K
D
E
D
D
K
K
P
K
L
E
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
45
39.6
67.6
N.A.
44.8
45
N.A.
42.9
40.5
39.3
36.9
N.A.
36.8
N.A.
34.1
N.A.
Protein Similarity:
100
45.5
44.4
68.9
N.A.
45.5
45.5
N.A.
44.7
43.1
42.7
43
N.A.
41.4
N.A.
41.3
N.A.
P-Site Identity:
100
93.3
13.3
93.3
N.A.
93.3
93.3
N.A.
80
73.3
66.6
0
N.A.
6.6
N.A.
0
N.A.
P-Site Similarity:
100
93.3
26.6
93.3
N.A.
93.3
93.3
N.A.
86.6
80
73.3
13.3
N.A.
6.6
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
35.4
31.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41.9
39.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
8
0
65
8
0
8
15
15
0
0
0
% D
% Glu:
15
22
8
8
8
8
0
8
8
79
0
0
8
15
8
% E
% Phe:
0
58
0
8
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
0
0
8
15
8
50
0
0
0
58
0
58
% G
% His:
8
0
0
0
0
0
0
0
15
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
8
0
15
8
0
0
8
0
0
0
% I
% Lys:
8
15
8
8
15
8
8
0
8
15
8
8
8
0
22
% K
% Leu:
0
0
0
15
0
22
0
0
0
0
8
15
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
36
0
0
0
% M
% Asn:
0
0
15
0
0
0
0
15
0
0
0
0
0
15
0
% N
% Pro:
0
0
0
0
0
0
0
8
0
0
58
0
0
15
0
% P
% Gln:
0
0
8
0
0
0
0
0
0
0
0
0
8
0
0
% Q
% Arg:
0
0
0
0
58
0
0
0
0
0
8
0
0
58
15
% R
% Ser:
72
8
0
0
0
0
0
0
8
0
0
15
0
0
0
% S
% Thr:
0
0
58
0
0
36
0
43
0
0
8
0
8
0
0
% T
% Val:
0
0
0
58
8
8
0
0
0
0
0
8
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _