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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HSP90AA2 All Species: 35.15
Human Site: Y197 Identified Species: 59.49
UniProt: Q14568 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14568 NP_005339 343 39365 Y197 L K E D Q T E Y L E E Q R I K
Chimpanzee Pan troglodytes A5A6K9 733 84754 Y197 L K E D Q T E Y L E E R R I K
Rhesus Macaque Macaca mulatta XP_001098426 696 80269 S462 L R Y H T S Q S G D E M T S L
Dog Lupus familis XP_848783 483 56243 Y197 L K E D Q T E Y L E E R R I K
Cat Felis silvestris
Mouse Mus musculus P07901 733 84769 Y197 L K E D Q T E Y L E E R R I K
Rat Rattus norvegicus P82995 733 84796 Y197 L K E D Q T E Y L E E R R I K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512830 733 84847 Y197 L K E D Q T E Y L E E R R I K
Chicken Gallus gallus P11501 728 84041 Y196 L K E D Q T E Y L E E R R I K
Frog Xenopus laevis NP_001085598 729 84174 Y198 L K E D Q S E Y F E E K R I K
Zebra Danio Brachydanio rerio Q90474 725 83300 D264 D E D E D S K D G K N K R K K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P02828 717 81847 D256 D E D A D K K D K D A K K K K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q18688 702 80265 A226 E D E E A V E A K D E E K K E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P55737 699 80046 S441 L R Y H S T K S G D E L T S L
Baker's Yeast Sacchar. cerevisiae P15108 705 80881 K255 E K K P K T K K V K E E V Q E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 45 39.6 67.6 N.A. 44.8 45 N.A. 42.9 40.5 39.3 36.9 N.A. 36.8 N.A. 34.1 N.A.
Protein Similarity: 100 45.5 44.4 68.9 N.A. 45.5 45.5 N.A. 44.7 43.1 42.7 43 N.A. 41.4 N.A. 41.3 N.A.
P-Site Identity: 100 93.3 13.3 93.3 N.A. 93.3 93.3 N.A. 93.3 93.3 80 13.3 N.A. 6.6 N.A. 20 N.A.
P-Site Similarity: 100 100 40 100 N.A. 100 100 N.A. 100 100 93.3 60 N.A. 46.6 N.A. 53.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 35.4 31.3 N.A.
Protein Similarity: N.A. N.A. N.A. 41.9 39.5 N.A.
P-Site Identity: N.A. N.A. N.A. 20 20 N.A.
P-Site Similarity: N.A. N.A. N.A. 40 66.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 8 0 0 8 0 0 8 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 15 8 15 58 15 0 0 15 0 29 0 0 0 0 0 % D
% Glu: 15 15 65 15 0 0 65 0 0 58 86 15 0 0 15 % E
% Phe: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 22 0 0 0 0 0 0 % G
% His: 0 0 0 15 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 58 0 % I
% Lys: 0 65 8 0 8 8 29 8 15 15 0 22 15 22 72 % K
% Leu: 72 0 0 0 0 0 0 0 50 0 0 8 0 0 15 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % N
% Pro: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 58 0 8 0 0 0 0 8 0 8 0 % Q
% Arg: 0 15 0 0 0 0 0 0 0 0 0 43 65 0 0 % R
% Ser: 0 0 0 0 8 22 0 15 0 0 0 0 0 15 0 % S
% Thr: 0 0 0 0 8 65 0 0 0 0 0 0 15 0 0 % T
% Val: 0 0 0 0 0 8 0 0 8 0 0 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 15 0 0 0 0 58 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _