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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IHH
All Species:
20.91
Human Site:
S221
Identified Species:
41.82
UniProt:
Q14623
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14623
NP_002172.2
411
45251
S221
S
G
A
R
V
A
L
S
A
V
R
P
G
D
R
Chimpanzee
Pan troglodytes
XP_526034
411
45281
S221
S
G
A
R
V
A
L
S
A
V
R
P
G
D
R
Rhesus Macaque
Macaca mulatta
XP_001092385
526
57459
S336
S
G
A
R
V
A
L
S
A
V
R
P
G
D
R
Dog
Lupus familis
XP_545653
373
40806
T201
M
G
E
D
G
N
P
T
F
S
D
V
L
I
F
Cat
Felis silvestris
Mouse
Mus musculus
P97812
411
45466
S221
N
G
E
R
V
A
L
S
A
V
K
P
G
D
R
Rat
Rattus norvegicus
Q63673
437
47612
K217
Q
G
G
T
K
L
V
K
D
L
S
P
G
D
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514443
688
74066
S481
S
G
A
L
V
E
L
S
S
L
R
P
G
D
R
Chicken
Gallus gallus
Q98938
408
44811
W217
N
G
A
R
T
P
L
W
A
L
R
P
G
Q
R
Frog
Xenopus laevis
Q91612
409
45573
S216
S
G
E
K
I
P
V
S
Q
L
S
P
G
L
R
Zebra Danio
Brachydanio rerio
Q90419
416
46558
K219
D
G
T
R
K
P
I
K
D
L
K
V
G
D
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q02936
471
52132
G276
S
G
V
R
K
P
L
G
E
L
S
I
G
D
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001012720
411
46240
L218
N
G
R
T
I
S
M
L
D
I
R
V
G
D
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
77.7
77.3
N.A.
95.1
59.2
N.A.
42.5
78
69.8
58.4
N.A.
41.4
N.A.
N.A.
48.6
Protein Similarity:
100
99.2
78.1
79.8
N.A.
97.5
68.4
N.A.
47
82.9
79
71.6
N.A.
55.6
N.A.
N.A.
65.2
P-Site Identity:
100
100
100
6.6
N.A.
80
33.3
N.A.
73.3
60
40
33.3
N.A.
46.6
N.A.
N.A.
26.6
P-Site Similarity:
100
100
100
13.3
N.A.
93.3
46.6
N.A.
86.6
73.3
66.6
53.3
N.A.
53.3
N.A.
N.A.
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
42
0
0
34
0
0
42
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
9
0
0
0
0
25
0
9
0
0
75
0
% D
% Glu:
0
0
25
0
0
9
0
0
9
0
0
0
0
0
9
% E
% Phe:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
9
% F
% Gly:
0
100
9
0
9
0
0
9
0
0
0
0
92
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
17
0
9
0
0
9
0
9
0
9
0
% I
% Lys:
0
0
0
9
25
0
0
17
0
0
17
0
0
0
0
% K
% Leu:
0
0
0
9
0
9
59
9
0
50
0
0
9
9
0
% L
% Met:
9
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% M
% Asn:
25
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
34
9
0
0
0
0
67
0
0
0
% P
% Gln:
9
0
0
0
0
0
0
0
9
0
0
0
0
9
0
% Q
% Arg:
0
0
9
59
0
0
0
0
0
0
50
0
0
0
84
% R
% Ser:
50
0
0
0
0
9
0
50
9
9
25
0
0
0
0
% S
% Thr:
0
0
9
17
9
0
0
9
0
0
0
0
0
0
0
% T
% Val:
0
0
9
0
42
0
17
0
0
34
0
25
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _