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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IHH
All Species:
26.67
Human Site:
S400
Identified Species:
53.33
UniProt:
Q14623
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14623
NP_002172.2
411
45251
S400
R
L
L
L
E
E
G
S
F
H
P
L
G
M
S
Chimpanzee
Pan troglodytes
XP_526034
411
45281
S400
R
L
L
L
E
E
G
S
F
H
P
L
G
M
S
Rhesus Macaque
Macaca mulatta
XP_001092385
526
57459
S515
R
L
L
L
E
E
G
S
F
H
P
L
G
M
S
Dog
Lupus familis
XP_545653
373
40806
S362
R
L
L
L
E
E
G
S
F
H
S
L
G
M
A
Cat
Felis silvestris
Mouse
Mus musculus
P97812
411
45466
T400
R
L
L
L
E
E
S
T
F
H
P
L
G
M
S
Rat
Rattus norvegicus
Q63673
437
47612
T426
T
W
L
L
D
S
E
T
L
H
P
L
G
M
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514443
688
74066
E676
A
C
R
R
G
R
G
E
R
D
P
R
R
E
N
Chicken
Gallus gallus
Q98938
408
44811
S397
R
M
L
L
P
P
D
S
F
H
P
L
G
A
P
Frog
Xenopus laevis
Q91612
409
45573
E398
R
L
I
L
H
G
N
E
F
H
P
L
G
I
V
Zebra Danio
Brachydanio rerio
Q90419
416
46558
S406
S
W
L
L
D
R
D
S
F
H
P
L
G
I
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q02936
471
52132
A453
Q
N
G
I
H
W
Y
A
N
A
L
Y
K
V
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001012720
411
46240
K398
Q
R
L
Y
K
L
G
K
Y
V
M
S
D
R
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
77.7
77.3
N.A.
95.1
59.2
N.A.
42.5
78
69.8
58.4
N.A.
41.4
N.A.
N.A.
48.6
Protein Similarity:
100
99.2
78.1
79.8
N.A.
97.5
68.4
N.A.
47
82.9
79
71.6
N.A.
55.6
N.A.
N.A.
65.2
P-Site Identity:
100
100
100
86.6
N.A.
86.6
46.6
N.A.
13.3
60
53.3
53.3
N.A.
0
N.A.
N.A.
13.3
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
66.6
N.A.
20
66.6
66.6
66.6
N.A.
26.6
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
0
0
0
9
0
9
0
0
0
9
17
% A
% Cys:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
17
0
17
0
0
9
0
0
9
0
0
% D
% Glu:
0
0
0
0
42
42
9
17
0
0
0
0
0
9
0
% E
% Phe:
0
0
0
0
0
0
0
0
67
0
0
0
0
0
0
% F
% Gly:
0
0
9
0
9
9
50
0
0
0
0
0
75
0
0
% G
% His:
0
0
0
0
17
0
0
0
0
75
0
0
0
0
0
% H
% Ile:
0
0
9
9
0
0
0
0
0
0
0
0
0
17
0
% I
% Lys:
0
0
0
0
9
0
0
9
0
0
0
0
9
0
9
% K
% Leu:
0
50
75
75
0
9
0
0
9
0
9
75
0
0
17
% L
% Met:
0
9
0
0
0
0
0
0
0
0
9
0
0
50
0
% M
% Asn:
0
9
0
0
0
0
9
0
9
0
0
0
0
0
9
% N
% Pro:
0
0
0
0
9
9
0
0
0
0
75
0
0
0
9
% P
% Gln:
17
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
59
9
9
9
0
17
0
0
9
0
0
9
9
9
0
% R
% Ser:
9
0
0
0
0
9
9
50
0
0
9
9
0
0
34
% S
% Thr:
9
0
0
0
0
0
0
17
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
9
0
0
0
9
9
% V
% Trp:
0
17
0
0
0
9
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
9
0
0
9
0
9
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _