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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLS1 All Species: 10.3
Human Site: S65 Identified Species: 20.61
UniProt: Q14651 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.27
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14651 NP_001138791.1 629 70253 S65 K I L S V A D S N K D G K I S
Chimpanzee Pan troglodytes XP_001157345 627 70271 L63 N L M A T G D L D Q D G R I S
Rhesus Macaque Macaca mulatta XP_001112046 629 70237 S65 K I I S V A D S N K D G K I S
Dog Lupus familis XP_542817 767 86003 N203 K I L A V A D N N K D G K I T
Cat Felis silvestris
Mouse Mus musculus Q3V0K9 630 70389 N65 K I L V V A D N N K D G K I S
Rat Rattus norvegicus Q63598 630 70661 R66 K L M L D G D R N K D G K I S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514284 674 75344 L110 N L M A T G E L N N G D K I S
Chicken Gallus gallus P19179 630 70921 S65 K I F A V T D S N K D G K I N
Frog Xenopus laevis NP_001083581 629 70942 K64 K L M N E G D K N K D G K I C
Zebra Danio Brachydanio rerio Q6P698 624 69882 L63 E I S R T M D L N Q D G K I T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q7G188 687 76910 S73 G M L G E L G S D T S T D V S
Baker's Yeast Sacchar. cerevisiae P32599 642 71754 K82 D Y V G L V A K L R E S K T G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 73.4 99.3 77 N.A. 94.2 74.9 N.A. 69.1 86.3 76.4 71.3 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 86.1 99.8 79.6 N.A. 97.4 87.4 N.A. 81.3 94.2 87.9 85.2 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 33.3 93.3 80 N.A. 86.6 60 N.A. 26.6 73.3 53.3 46.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 73.3 100 100 N.A. 93.3 73.3 N.A. 53.3 86.6 73.3 66.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 35.2 39.5 N.A.
Protein Similarity: N.A. N.A. N.A. 57.6 59.3 N.A.
P-Site Identity: N.A. N.A. N.A. 20 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 40 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 34 0 34 9 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % C
% Asp: 9 0 0 0 9 0 75 0 17 0 75 9 9 0 0 % D
% Glu: 9 0 0 0 17 0 9 0 0 0 9 0 0 0 0 % E
% Phe: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 9 0 0 17 0 34 9 0 0 0 9 75 0 0 9 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 50 9 0 0 0 0 0 0 0 0 0 0 84 0 % I
% Lys: 59 0 0 0 0 0 0 17 0 59 0 0 84 0 0 % K
% Leu: 0 34 34 9 9 9 0 25 9 0 0 0 0 0 0 % L
% Met: 0 9 34 0 0 9 0 0 0 0 0 0 0 0 0 % M
% Asn: 17 0 0 9 0 0 0 17 75 9 0 0 0 0 9 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 17 0 0 0 0 0 % Q
% Arg: 0 0 0 9 0 0 0 9 0 9 0 0 9 0 0 % R
% Ser: 0 0 9 17 0 0 0 34 0 0 9 9 0 0 59 % S
% Thr: 0 0 0 0 25 9 0 0 0 9 0 9 0 9 17 % T
% Val: 0 0 9 9 42 9 0 0 0 0 0 0 0 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _