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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MELK
All Species:
14.85
Human Site:
S336
Identified Species:
23.33
UniProt:
Q14680
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14680
NP_055606.1
651
74642
S336
P
V
R
L
R
L
S
S
F
S
C
G
Q
A
S
Chimpanzee
Pan troglodytes
XP_001168921
651
74605
S336
P
V
H
L
R
L
S
S
F
S
C
G
Q
A
S
Rhesus Macaque
Macaca mulatta
XP_001115076
651
74642
S336
P
V
R
L
R
L
S
S
F
S
C
G
Q
A
S
Dog
Lupus familis
XP_538730
651
74149
S336
P
V
R
L
R
L
P
S
F
S
C
G
L
A
S
Cat
Felis silvestris
Mouse
Mus musculus
Q61846
643
72695
K328
L
A
K
K
A
R
G
K
P
A
R
L
Q
L
P
Rat
Rattus norvegicus
P54645
559
63955
L260
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509217
655
73776
F340
R
L
R
L
L
S
T
F
H
G
Q
T
G
F
T
Chicken
Gallus gallus
NP_001026680
657
74208
H342
R
I
P
S
Q
T
G
H
A
S
T
T
Q
S
A
Frog
Xenopus laevis
NP_001081569
651
74289
H336
G
K
A
V
R
L
K
H
P
L
A
V
G
D
Q
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
N593
R
S
S
Y
K
D
C
N
T
L
H
L
P
M
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395000
606
68302
S307
I
W
K
K
L
V
K
S
D
R
T
D
Y
K
T
Nematode Worm
Caenorhab. elegans
NP_001023420
703
79966
A389
S
S
S
S
D
I
S
A
R
L
K
K
N
C
V
Sea Urchin
Strong. purpuratus
XP_781767
971
109658
S656
S
S
P
Y
M
F
S
S
M
E
D
G
L
E
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q2V452
441
50581
E141
Y
H
R
D
L
K
P
E
N
L
L
L
D
S
Y
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
E328
P
H
P
E
E
E
N
E
N
N
D
S
K
K
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96.4
91.7
N.A.
83.4
29.6
N.A.
70.8
61.7
66.2
20.2
N.A.
N.A.
39.9
37.9
32.7
Protein Similarity:
100
99.5
97.5
95.8
N.A.
90.3
47.4
N.A.
80.1
75.9
80.3
34.1
N.A.
N.A.
55.7
56
45.5
P-Site Identity:
100
93.3
100
86.6
N.A.
6.6
6.6
N.A.
13.3
13.3
13.3
0
N.A.
N.A.
6.6
6.6
20
P-Site Similarity:
100
93.3
100
86.6
N.A.
20
13.3
N.A.
33.3
40
20
13.3
N.A.
N.A.
26.6
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.8
27
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.5
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
0
7
0
0
7
7
7
7
0
0
27
7
% A
% Cys:
0
0
0
0
0
0
7
0
0
0
27
0
0
7
0
% C
% Asp:
0
0
0
7
7
7
0
0
7
0
20
7
7
7
14
% D
% Glu:
0
0
0
7
7
7
0
14
0
7
0
0
0
7
7
% E
% Phe:
0
0
0
0
0
7
0
7
27
0
0
0
0
7
0
% F
% Gly:
7
0
0
0
0
0
14
0
0
7
0
34
14
0
0
% G
% His:
0
14
7
0
0
7
0
14
7
0
7
0
0
0
0
% H
% Ile:
14
7
0
0
0
7
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
7
14
14
14
7
14
7
0
0
7
7
7
20
0
% K
% Leu:
7
7
7
40
20
34
0
7
0
27
7
20
14
7
0
% L
% Met:
0
0
0
0
7
0
7
0
7
0
0
0
7
7
0
% M
% Asn:
0
0
0
0
0
0
7
7
14
7
0
0
7
0
0
% N
% Pro:
34
0
20
0
0
0
14
0
14
0
0
7
7
0
7
% P
% Gln:
0
0
0
0
7
0
0
0
7
0
7
0
34
0
7
% Q
% Arg:
20
0
34
0
34
7
0
0
7
7
7
0
0
0
7
% R
% Ser:
14
27
14
14
0
7
34
40
0
34
0
7
0
14
27
% S
% Thr:
0
0
0
0
0
7
7
0
7
0
14
14
0
0
14
% T
% Val:
0
27
0
7
0
7
0
0
0
7
0
7
0
0
7
% V
% Trp:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
14
0
0
0
0
0
0
0
0
7
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _