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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MELK All Species: 12.42
Human Site: S356 Identified Species: 19.52
UniProt: Q14680 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14680 NP_055606.1 651 74642 S356 D I K S N N W S L E D V T A S
Chimpanzee Pan troglodytes XP_001168921 651 74605 S356 D I K S N N W S L E D V T A S
Rhesus Macaque Macaca mulatta XP_001115076 651 74642 S356 D I K S K N R S L E D V T T S
Dog Lupus familis XP_538730 651 74149 S356 N I K S K N L S L E D M T T S
Cat Felis silvestris
Mouse Mus musculus Q61846 643 72695 S348 T A S T T P K S K N L S L E D
Rat Rattus norvegicus P54645 559 63955 K280 I R E H E W F K Q D L P K Y L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509217 655 73776 D360 L N L E E A G D H A S S L E V
Chicken Gallus gallus NP_001026680 657 74208 V362 K A M T Y E D V P D C S D V P
Frog Xenopus laevis NP_001081569 651 74289 K356 K E L R P K S K L D F E E P N
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 A613 R R F S D G A A T I Q A Y K T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_395000 606 68302 G327 L L D R K L R G L S L R I S S
Nematode Worm Caenorhab. elegans NP_001023420 703 79966 P409 S S S R F V K P M S P A A E K
Sea Urchin Strong. purpuratus XP_781767 971 109658 R676 I T S S P H R R T A S E R R H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q2V452 441 50581 L161 S D F G L S A L S Q Q V R D D
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 L348 N D E I D D N L V N I L S S T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 96.4 91.7 N.A. 83.4 29.6 N.A. 70.8 61.7 66.2 20.2 N.A. N.A. 39.9 37.9 32.7
Protein Similarity: 100 99.5 97.5 95.8 N.A. 90.3 47.4 N.A. 80.1 75.9 80.3 34.1 N.A. N.A. 55.7 56 45.5
P-Site Identity: 100 100 80 66.6 N.A. 6.6 0 N.A. 0 0 6.6 6.6 N.A. N.A. 13.3 0 6.6
P-Site Similarity: 100 100 80 80 N.A. 13.3 20 N.A. 0 13.3 20 26.6 N.A. N.A. 26.6 6.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. 28.8 27 N.A.
Protein Similarity: N.A. N.A. N.A. 44.5 47.1 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 14 0 0 0 7 14 7 0 14 0 14 7 14 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % C
% Asp: 20 14 7 0 14 7 7 7 0 20 27 0 7 7 14 % D
% Glu: 0 7 14 7 14 7 0 0 0 27 0 14 7 20 0 % E
% Phe: 0 0 14 0 7 0 7 0 0 0 7 0 0 0 0 % F
% Gly: 0 0 0 7 0 7 7 7 0 0 0 0 0 0 0 % G
% His: 0 0 0 7 0 7 0 0 7 0 0 0 0 0 7 % H
% Ile: 14 27 0 7 0 0 0 0 0 7 7 0 7 0 0 % I
% Lys: 14 0 27 0 20 7 14 14 7 0 0 0 7 7 7 % K
% Leu: 14 7 14 0 7 7 7 14 40 0 20 7 14 0 7 % L
% Met: 0 0 7 0 0 0 0 0 7 0 0 7 0 0 0 % M
% Asn: 14 7 0 0 14 27 7 0 0 14 0 0 0 0 7 % N
% Pro: 0 0 0 0 14 7 0 7 7 0 7 7 0 7 7 % P
% Gln: 0 0 0 0 0 0 0 0 7 7 14 0 0 0 0 % Q
% Arg: 7 14 0 20 0 0 20 7 0 0 0 7 14 7 0 % R
% Ser: 14 7 20 40 0 7 7 34 7 14 14 20 7 14 34 % S
% Thr: 7 7 0 14 7 0 0 0 14 0 0 0 27 14 14 % T
% Val: 0 0 0 0 0 7 0 7 7 0 0 27 0 7 7 % V
% Trp: 0 0 0 0 0 7 14 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 0 0 0 0 0 0 0 7 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _