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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MELK All Species: 11.82
Human Site: S391 Identified Species: 18.57
UniProt: Q14680 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14680 NP_055606.1 651 74642 S391 G A A T P R T S Q F T K Y W T
Chimpanzee Pan troglodytes XP_001168921 651 74605 S391 G A A T P R T S Q F T K Y W T
Rhesus Macaque Macaca mulatta XP_001115076 651 74642 S391 G A A T P Q K S Q F T K Y W T
Dog Lupus familis XP_538730 651 74149 P391 G V A T P Q T P Q F A K H W T
Cat Felis silvestris
Mouse Mus musculus Q61846 643 72695 P383 K L L A P K T P Q V T K H L A
Rat Rattus norvegicus P54645 559 63955 E315 C E K F E C S E E E V L S C L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509217 655 73776 T395 G P N I A P K T E L A K H Q T
Chicken Gallus gallus NP_001026680 657 74208 H397 E E F S L N T H R T K Q H S R
Frog Xenopus laevis NP_001081569 651 74289 E391 D F T Y S S F E P H T P K E Y
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 E648 M Y A A P Q D E R L M E H T Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_395000 606 68302 K362 L D Y S P R S K S V R S P I I
Nematode Worm Caenorhab. elegans NP_001023420 703 79966 S444 S P L R I P E S P M S V R S S
Sea Urchin Strong. purpuratus XP_781767 971 109658 K711 N L D G T Y V K P G D L L G E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q2V452 441 50581 A196 R G Y D G A T A D M W S C G V
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 Y383 F N E I R D A Y M L I K E N K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 96.4 91.7 N.A. 83.4 29.6 N.A. 70.8 61.7 66.2 20.2 N.A. N.A. 39.9 37.9 32.7
Protein Similarity: 100 99.5 97.5 95.8 N.A. 90.3 47.4 N.A. 80.1 75.9 80.3 34.1 N.A. N.A. 55.7 56 45.5
P-Site Identity: 100 100 86.6 66.6 N.A. 33.3 0 N.A. 20 6.6 6.6 13.3 N.A. N.A. 13.3 6.6 0
P-Site Similarity: 100 100 93.3 80 N.A. 46.6 13.3 N.A. 40 33.3 6.6 40 N.A. N.A. 26.6 20 0
Percent
Protein Identity: N.A. N.A. N.A. 28.8 27 N.A.
Protein Similarity: N.A. N.A. N.A. 44.5 47.1 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 20 34 14 7 7 7 7 0 0 14 0 0 0 7 % A
% Cys: 7 0 0 0 0 7 0 0 0 0 0 0 7 7 0 % C
% Asp: 7 7 7 7 0 7 7 0 7 0 7 0 0 0 0 % D
% Glu: 7 14 7 0 7 0 7 20 14 7 0 7 7 7 7 % E
% Phe: 7 7 7 7 0 0 7 0 0 27 0 0 0 0 0 % F
% Gly: 34 7 0 7 7 0 0 0 0 7 0 0 0 14 0 % G
% His: 0 0 0 0 0 0 0 7 0 7 0 0 34 0 0 % H
% Ile: 0 0 0 14 7 0 0 0 0 0 7 0 0 7 7 % I
% Lys: 7 0 7 0 0 7 14 14 0 0 7 47 7 0 7 % K
% Leu: 7 14 14 0 7 0 0 0 0 20 0 14 7 7 7 % L
% Met: 7 0 0 0 0 0 0 0 7 14 7 0 0 0 0 % M
% Asn: 7 7 7 0 0 7 0 0 0 0 0 0 0 7 0 % N
% Pro: 0 14 0 0 47 14 0 14 20 0 0 7 7 0 0 % P
% Gln: 0 0 0 0 0 20 0 0 34 0 0 7 0 7 7 % Q
% Arg: 7 0 0 7 7 20 0 0 14 0 7 0 7 0 7 % R
% Ser: 7 0 0 14 7 7 14 27 7 0 7 14 7 14 7 % S
% Thr: 0 0 7 27 7 0 40 7 0 7 34 0 0 7 34 % T
% Val: 0 7 0 0 0 0 7 0 0 14 7 7 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 7 0 0 27 0 % W
% Tyr: 0 7 14 7 0 7 0 7 0 0 0 0 20 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _