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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MELK
All Species:
21.82
Human Site:
S468
Identified Species:
34.29
UniProt:
Q14680
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14680
NP_055606.1
651
74642
S468
P
N
R
Y
T
T
P
S
K
A
R
N
Q
C
L
Chimpanzee
Pan troglodytes
XP_001168921
651
74605
S468
P
N
R
Y
T
T
P
S
K
A
R
N
Q
C
L
Rhesus Macaque
Macaca mulatta
XP_001115076
651
74642
S468
P
N
R
Y
A
A
P
S
K
A
R
N
Q
C
L
Dog
Lupus familis
XP_538730
651
74149
S468
P
N
H
Y
T
T
P
S
K
A
R
N
Q
C
L
Cat
Felis silvestris
Mouse
Mus musculus
Q61846
643
72695
A460
P
T
R
F
P
T
P
A
K
A
R
A
Q
C
L
Rat
Rattus norvegicus
P54645
559
63955
L392
A
R
H
T
L
D
E
L
N
P
Q
K
S
K
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509217
655
73776
S472
P
N
S
R
T
L
P
S
K
E
K
D
Q
S
Q
Chicken
Gallus gallus
NP_001026680
657
74208
T474
G
I
P
F
Q
A
P
T
S
K
E
S
Q
F
T
Frog
Xenopus laevis
NP_001081569
651
74289
K468
G
I
L
T
T
P
N
K
N
T
Q
T
K
E
K
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
G725
S
S
P
P
P
P
G
G
G
A
G
L
M
Q
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395000
606
68302
T439
S
R
E
S
Q
S
C
T
P
G
S
A
R
K
V
Nematode Worm
Caenorhab. elegans
NP_001023420
703
79966
F521
R
P
T
L
R
G
L
F
S
P
G
N
A
E
H
Sea Urchin
Strong. purpuratus
XP_781767
971
109658
T788
L
S
L
P
P
V
V
T
P
S
R
S
M
D
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q2V452
441
50581
Y273
D
E
W
F
K
K
D
Y
K
P
P
V
F
E
E
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
Y460
Q
S
P
F
M
D
Q
Y
K
E
E
D
S
T
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96.4
91.7
N.A.
83.4
29.6
N.A.
70.8
61.7
66.2
20.2
N.A.
N.A.
39.9
37.9
32.7
Protein Similarity:
100
99.5
97.5
95.8
N.A.
90.3
47.4
N.A.
80.1
75.9
80.3
34.1
N.A.
N.A.
55.7
56
45.5
P-Site Identity:
100
100
86.6
93.3
N.A.
66.6
0
N.A.
46.6
13.3
6.6
6.6
N.A.
N.A.
0
6.6
6.6
P-Site Similarity:
100
100
86.6
93.3
N.A.
80
6.6
N.A.
60
33.3
20
13.3
N.A.
N.A.
26.6
6.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.8
27
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.5
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
7
14
0
7
0
40
0
14
7
0
0
% A
% Cys:
0
0
0
0
0
0
7
0
0
0
0
0
0
34
0
% C
% Asp:
7
0
0
0
0
14
7
0
0
0
0
14
0
7
0
% D
% Glu:
0
7
7
0
0
0
7
0
0
14
14
0
0
20
7
% E
% Phe:
0
0
0
27
0
0
0
7
0
0
0
0
7
7
0
% F
% Gly:
14
0
0
0
0
7
7
7
7
7
14
0
0
0
7
% G
% His:
0
0
14
0
0
0
0
0
0
0
0
0
0
0
14
% H
% Ile:
0
14
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
7
7
0
7
54
7
7
7
7
14
7
% K
% Leu:
7
0
14
7
7
7
7
7
0
0
0
7
0
0
34
% L
% Met:
0
0
0
0
7
0
0
0
0
0
0
0
14
0
0
% M
% Asn:
0
34
0
0
0
0
7
0
14
0
0
34
0
0
0
% N
% Pro:
40
7
20
14
20
14
47
0
14
20
7
0
0
0
0
% P
% Gln:
7
0
0
0
14
0
7
0
0
0
14
0
47
7
7
% Q
% Arg:
7
14
27
7
7
0
0
0
0
0
40
0
7
0
0
% R
% Ser:
14
20
7
7
0
7
0
34
14
7
7
14
14
7
0
% S
% Thr:
0
7
7
14
34
27
0
20
0
7
0
7
0
7
14
% T
% Val:
0
0
0
0
0
7
7
0
0
0
0
7
0
0
14
% V
% Trp:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
27
0
0
0
14
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _