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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MELK All Species: 18.18
Human Site: S486 Identified Species: 28.57
UniProt: Q14680 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14680 NP_055606.1 651 74642 S486 P I K I P V N S T G T D K L M
Chimpanzee Pan troglodytes XP_001168921 651 74605 S486 P I K I P V N S T G T D K L M
Rhesus Macaque Macaca mulatta XP_001115076 651 74642 S486 P I K M P V N S T G T D K L M
Dog Lupus familis XP_538730 651 74149 S486 P I K M P I N S A G T E K L M
Cat Felis silvestris
Mouse Mus musculus Q61846 643 72695 S478 P V R T P G N S A G A D T L T
Rat Rattus norvegicus P54645 559 63955 G410 R K A K W H L G I R S Q S R P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509217 655 73776 S490 T M K T F T D S D I S T D L V
Chicken Gallus gallus NP_001026680 657 74208 P492 P V K K P K T P T N T C E L T
Frog Xenopus laevis NP_001081569 651 74289 P486 K E T P T K K P I G T G E E F
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 H743 P S A V Q Y Q H G S A L Y Q S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_395000 606 68302 V457 L E R G L N R V R Y V L T P K
Nematode Worm Caenorhab. elegans NP_001023420 703 79966 R539 Q R A R S S D R A S I G M P P
Sea Urchin Strong. purpuratus XP_781767 971 109658 R806 R L S V N S A R S T G A F D I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q2V452 441 50581 A291 S N M D D I D A V F K D S E E
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 H478 P T S L P Q I H R A N M L A Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 96.4 91.7 N.A. 83.4 29.6 N.A. 70.8 61.7 66.2 20.2 N.A. N.A. 39.9 37.9 32.7
Protein Similarity: 100 99.5 97.5 95.8 N.A. 90.3 47.4 N.A. 80.1 75.9 80.3 34.1 N.A. N.A. 55.7 56 45.5
P-Site Identity: 100 100 93.3 73.3 N.A. 46.6 0 N.A. 20 40 13.3 6.6 N.A. N.A. 0 0 0
P-Site Similarity: 100 100 100 93.3 N.A. 60 6.6 N.A. 46.6 53.3 20 13.3 N.A. N.A. 6.6 6.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. 28.8 27 N.A.
Protein Similarity: N.A. N.A. N.A. 44.5 47.1 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 20 0 0 0 7 7 20 7 14 7 0 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % C
% Asp: 0 0 0 7 7 0 20 0 7 0 0 34 7 7 0 % D
% Glu: 0 14 0 0 0 0 0 0 0 0 0 7 14 14 7 % E
% Phe: 0 0 0 0 7 0 0 0 0 7 0 0 7 0 7 % F
% Gly: 0 0 0 7 0 7 0 7 7 40 7 14 0 0 0 % G
% His: 0 0 0 0 0 7 0 14 0 0 0 0 0 0 0 % H
% Ile: 0 27 0 14 0 14 7 0 14 7 7 0 0 0 7 % I
% Lys: 7 7 40 14 0 14 7 0 0 0 7 0 27 0 7 % K
% Leu: 7 7 0 7 7 0 7 0 0 0 0 14 7 47 0 % L
% Met: 0 7 7 14 0 0 0 0 0 0 0 7 7 0 27 % M
% Asn: 0 7 0 0 7 7 34 0 0 7 7 0 0 0 0 % N
% Pro: 54 0 0 7 47 0 0 14 0 0 0 0 0 14 14 % P
% Gln: 7 0 0 0 7 7 7 0 0 0 0 7 0 7 7 % Q
% Arg: 14 7 14 7 0 0 7 14 14 7 0 0 0 7 0 % R
% Ser: 7 7 14 0 7 14 0 40 7 14 14 0 14 0 7 % S
% Thr: 7 7 7 14 7 7 7 0 27 7 40 7 14 0 14 % T
% Val: 0 14 0 14 0 20 0 7 7 0 7 0 0 0 7 % V
% Trp: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 7 0 0 0 7 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _