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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MELK
All Species:
18.18
Human Site:
S486
Identified Species:
28.57
UniProt:
Q14680
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14680
NP_055606.1
651
74642
S486
P
I
K
I
P
V
N
S
T
G
T
D
K
L
M
Chimpanzee
Pan troglodytes
XP_001168921
651
74605
S486
P
I
K
I
P
V
N
S
T
G
T
D
K
L
M
Rhesus Macaque
Macaca mulatta
XP_001115076
651
74642
S486
P
I
K
M
P
V
N
S
T
G
T
D
K
L
M
Dog
Lupus familis
XP_538730
651
74149
S486
P
I
K
M
P
I
N
S
A
G
T
E
K
L
M
Cat
Felis silvestris
Mouse
Mus musculus
Q61846
643
72695
S478
P
V
R
T
P
G
N
S
A
G
A
D
T
L
T
Rat
Rattus norvegicus
P54645
559
63955
G410
R
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509217
655
73776
S490
T
M
K
T
F
T
D
S
D
I
S
T
D
L
V
Chicken
Gallus gallus
NP_001026680
657
74208
P492
P
V
K
K
P
K
T
P
T
N
T
C
E
L
T
Frog
Xenopus laevis
NP_001081569
651
74289
P486
K
E
T
P
T
K
K
P
I
G
T
G
E
E
F
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
H743
P
S
A
V
Q
Y
Q
H
G
S
A
L
Y
Q
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395000
606
68302
V457
L
E
R
G
L
N
R
V
R
Y
V
L
T
P
K
Nematode Worm
Caenorhab. elegans
NP_001023420
703
79966
R539
Q
R
A
R
S
S
D
R
A
S
I
G
M
P
P
Sea Urchin
Strong. purpuratus
XP_781767
971
109658
R806
R
L
S
V
N
S
A
R
S
T
G
A
F
D
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q2V452
441
50581
A291
S
N
M
D
D
I
D
A
V
F
K
D
S
E
E
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
H478
P
T
S
L
P
Q
I
H
R
A
N
M
L
A
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96.4
91.7
N.A.
83.4
29.6
N.A.
70.8
61.7
66.2
20.2
N.A.
N.A.
39.9
37.9
32.7
Protein Similarity:
100
99.5
97.5
95.8
N.A.
90.3
47.4
N.A.
80.1
75.9
80.3
34.1
N.A.
N.A.
55.7
56
45.5
P-Site Identity:
100
100
93.3
73.3
N.A.
46.6
0
N.A.
20
40
13.3
6.6
N.A.
N.A.
0
0
0
P-Site Similarity:
100
100
100
93.3
N.A.
60
6.6
N.A.
46.6
53.3
20
13.3
N.A.
N.A.
6.6
6.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.8
27
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.5
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
20
0
0
0
7
7
20
7
14
7
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% C
% Asp:
0
0
0
7
7
0
20
0
7
0
0
34
7
7
0
% D
% Glu:
0
14
0
0
0
0
0
0
0
0
0
7
14
14
7
% E
% Phe:
0
0
0
0
7
0
0
0
0
7
0
0
7
0
7
% F
% Gly:
0
0
0
7
0
7
0
7
7
40
7
14
0
0
0
% G
% His:
0
0
0
0
0
7
0
14
0
0
0
0
0
0
0
% H
% Ile:
0
27
0
14
0
14
7
0
14
7
7
0
0
0
7
% I
% Lys:
7
7
40
14
0
14
7
0
0
0
7
0
27
0
7
% K
% Leu:
7
7
0
7
7
0
7
0
0
0
0
14
7
47
0
% L
% Met:
0
7
7
14
0
0
0
0
0
0
0
7
7
0
27
% M
% Asn:
0
7
0
0
7
7
34
0
0
7
7
0
0
0
0
% N
% Pro:
54
0
0
7
47
0
0
14
0
0
0
0
0
14
14
% P
% Gln:
7
0
0
0
7
7
7
0
0
0
0
7
0
7
7
% Q
% Arg:
14
7
14
7
0
0
7
14
14
7
0
0
0
7
0
% R
% Ser:
7
7
14
0
7
14
0
40
7
14
14
0
14
0
7
% S
% Thr:
7
7
7
14
7
7
7
0
27
7
40
7
14
0
14
% T
% Val:
0
14
0
14
0
20
0
7
7
0
7
0
0
0
7
% V
% Trp:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
7
0
0
0
7
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _