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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MELK All Species: 20.61
Human Site: S544 Identified Species: 32.38
UniProt: Q14680 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.21
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14680 NP_055606.1 651 74642 S544 V I T V L T R S K R K G S A R
Chimpanzee Pan troglodytes XP_001168921 651 74605 S544 V I T V L T R S K R K G S A R
Rhesus Macaque Macaca mulatta XP_001115076 651 74642 S544 V I T V L T R S K R K G C A R
Dog Lupus familis XP_538730 651 74149 S544 V I T V L T R S K K K G S A K
Cat Felis silvestris
Mouse Mus musculus Q61846 643 72695 N536 V L T A L T R N K K K G S A R
Rat Rattus norvegicus P54645 559 63955 R468 Q L Y Q V D S R T Y L L D F R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509217 655 73776 S548 V I T M L T P S K R K D S T R
Chicken Gallus gallus NP_001026680 657 74208 G550 V I T M L T P G K K K R F S R
Frog Xenopus laevis NP_001081569 651 74289 S544 M I T M L T P S K R K G Y T R
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 G801 Q E V E L G G G A Q R Q S F L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_395000 606 68302 H515 R R K G I M C H Q K G F I L Q
Nematode Worm Caenorhab. elegans NP_001023420 703 79966 R597 L I T L L T P R K M Q R D S P
Sea Urchin Strong. purpuratus XP_781767 971 109658 R864 I D L L S P R R R S T A G I D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q2V452 441 50581 N349 I T L R G G A N E I I E K I E
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 P536 L G A E W A K P S E E D L W T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 96.4 91.7 N.A. 83.4 29.6 N.A. 70.8 61.7 66.2 20.2 N.A. N.A. 39.9 37.9 32.7
Protein Similarity: 100 99.5 97.5 95.8 N.A. 90.3 47.4 N.A. 80.1 75.9 80.3 34.1 N.A. N.A. 55.7 56 45.5
P-Site Identity: 100 100 93.3 86.6 N.A. 73.3 6.6 N.A. 73.3 53.3 66.6 13.3 N.A. N.A. 0 33.3 6.6
P-Site Similarity: 100 100 93.3 100 N.A. 93.3 20 N.A. 80 73.3 80 26.6 N.A. N.A. 26.6 60 26.6
Percent
Protein Identity: N.A. N.A. N.A. 28.8 27 N.A.
Protein Similarity: N.A. N.A. N.A. 44.5 47.1 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 7 0 7 7 0 7 0 0 7 0 34 0 % A
% Cys: 0 0 0 0 0 0 7 0 0 0 0 0 7 0 0 % C
% Asp: 0 7 0 0 0 7 0 0 0 0 0 14 14 0 7 % D
% Glu: 0 7 0 14 0 0 0 0 7 7 7 7 0 0 7 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 7 7 14 0 % F
% Gly: 0 7 0 7 7 14 7 14 0 0 7 40 7 0 0 % G
% His: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % H
% Ile: 14 54 0 0 7 0 0 0 0 7 7 0 7 14 0 % I
% Lys: 0 0 7 0 0 0 7 0 60 27 54 0 7 0 7 % K
% Leu: 14 14 14 14 67 0 0 0 0 0 7 7 7 7 7 % L
% Met: 7 0 0 20 0 7 0 0 0 7 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 14 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 7 27 7 0 0 0 0 0 0 7 % P
% Gln: 14 0 0 7 0 0 0 0 7 7 7 7 0 0 7 % Q
% Arg: 7 7 0 7 0 0 40 20 7 34 7 14 0 0 54 % R
% Ser: 0 0 0 0 7 0 7 40 7 7 0 0 40 14 0 % S
% Thr: 0 7 60 0 0 60 0 0 7 0 7 0 0 14 7 % T
% Val: 47 0 7 27 7 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 7 0 0 0 0 0 0 0 0 7 0 % W
% Tyr: 0 0 7 0 0 0 0 0 0 7 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _