KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MELK
All Species:
17.58
Human Site:
T345
Identified Species:
27.62
UniProt:
Q14680
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14680
NP_055606.1
651
74642
T345
S
C
G
Q
A
S
A
T
P
F
T
D
I
K
S
Chimpanzee
Pan troglodytes
XP_001168921
651
74605
T345
S
C
G
Q
A
S
A
T
P
F
T
D
I
K
S
Rhesus Macaque
Macaca mulatta
XP_001115076
651
74642
T345
S
C
G
Q
A
S
A
T
P
F
T
D
I
K
S
Dog
Lupus familis
XP_538730
651
74149
T345
S
C
G
L
A
S
A
T
P
F
T
N
I
K
S
Cat
Felis silvestris
Mouse
Mus musculus
Q61846
643
72695
F337
A
R
L
Q
L
P
S
F
S
C
G
T
A
S
T
Rat
Rattus norvegicus
P54645
559
63955
T269
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509217
655
73776
R349
G
Q
T
G
F
T
P
R
A
K
N
L
N
L
E
Chicken
Gallus gallus
NP_001026680
657
74208
L351
S
T
T
Q
S
A
S
L
G
S
E
K
A
M
T
Frog
Xenopus laevis
NP_001081569
651
74289
V345
L
A
V
G
D
Q
A
V
T
S
F
K
E
L
R
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
F602
L
H
L
P
M
E
R
F
S
P
V
R
R
F
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395000
606
68302
T316
R
T
D
Y
K
T
A
T
Y
L
L
L
L
D
R
Nematode Worm
Caenorhab. elegans
NP_001023420
703
79966
S398
L
K
K
N
C
V
V
S
D
E
S
S
S
S
R
Sea Urchin
Strong. purpuratus
XP_781767
971
109658
E665
E
D
G
L
E
D
E
E
S
Y
I
I
T
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q2V452
441
50581
N150
L
L
L
D
S
Y
G
N
L
K
I
S
D
F
G
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
S337
N
D
S
K
K
D
G
S
S
P
D
N
D
E
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96.4
91.7
N.A.
83.4
29.6
N.A.
70.8
61.7
66.2
20.2
N.A.
N.A.
39.9
37.9
32.7
Protein Similarity:
100
99.5
97.5
95.8
N.A.
90.3
47.4
N.A.
80.1
75.9
80.3
34.1
N.A.
N.A.
55.7
56
45.5
P-Site Identity:
100
100
100
86.6
N.A.
6.6
13.3
N.A.
0
13.3
6.6
6.6
N.A.
N.A.
13.3
0
13.3
P-Site Similarity:
100
100
100
93.3
N.A.
26.6
20
N.A.
6.6
40
6.6
6.6
N.A.
N.A.
26.6
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.8
27
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.5
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
0
27
7
47
0
7
0
0
0
14
0
0
% A
% Cys:
0
27
0
0
7
0
0
0
0
7
0
0
0
0
0
% C
% Asp:
0
20
7
7
7
14
0
0
7
0
14
20
14
7
0
% D
% Glu:
7
0
0
0
7
7
7
7
0
7
7
0
7
14
7
% E
% Phe:
0
0
0
0
7
0
0
14
0
27
7
0
0
14
0
% F
% Gly:
7
0
34
14
0
0
14
0
7
0
7
0
0
0
7
% G
% His:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
0
0
0
0
0
0
0
0
7
0
14
14
27
0
7
% I
% Lys:
0
7
7
7
20
0
0
0
0
20
0
14
0
27
0
% K
% Leu:
27
7
20
14
7
0
0
7
7
7
7
14
7
14
0
% L
% Met:
0
0
0
7
7
0
0
0
0
0
0
0
0
7
0
% M
% Asn:
7
0
0
7
0
0
0
7
0
0
7
14
7
0
0
% N
% Pro:
0
0
7
7
0
7
7
0
27
14
0
0
0
0
0
% P
% Gln:
0
7
0
34
0
7
0
0
0
0
0
0
0
0
0
% Q
% Arg:
7
7
0
0
0
7
7
7
0
0
0
7
14
0
20
% R
% Ser:
34
0
7
0
14
27
14
14
27
14
7
14
7
20
40
% S
% Thr:
0
14
14
0
0
14
0
40
7
0
27
7
7
0
14
% T
% Val:
7
0
7
0
0
7
7
7
0
0
7
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
7
0
7
0
0
7
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _