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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MELK All Species: 10.3
Human Site: T415 Identified Species: 16.19
UniProt: Q14680 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14680 NP_055606.1 651 74642 T415 L T P A L C R T P A N K L K N
Chimpanzee Pan troglodytes XP_001168921 651 74605 T415 L T P A L C R T P A N K L K N
Rhesus Macaque Macaca mulatta XP_001115076 651 74642 T415 L T P A L C R T P A N K L K N
Dog Lupus familis XP_538730 651 74149 A415 L T P V L C R A S A D K L K N
Cat Felis silvestris
Mouse Mus musculus Q61846 643 72695 A407 P A P G V R R A V A N K L M D
Rat Rattus norvegicus P54645 559 63955 I339 A V A Y H L I I D N R R I M N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509217 655 73776 A419 L T P V I R R A A K K K S E N
Chicken Gallus gallus NP_001026680 657 74208 T421 F T L S T P V T R K V A S K K
Frog Xenopus laevis NP_001081569 651 74289 P415 V D S A P A T P V V Q R N A R
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 I672 Q Q I L H Q Q I Q A L S L G H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_395000 606 68302 F386 T P E T T N N F M E P H L P G
Nematode Worm Caenorhab. elegans NP_001023420 703 79966 K468 T P S R G G V K D N D K E N A
Sea Urchin Strong. purpuratus XP_781767 971 109658 R735 V S G K E N H R D N E G F V K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q2V452 441 50581 L220 L P F D D S N L M N L Y K K I
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 D407 K S V S D E L D T F L S Q S P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 96.4 91.7 N.A. 83.4 29.6 N.A. 70.8 61.7 66.2 20.2 N.A. N.A. 39.9 37.9 32.7
Protein Similarity: 100 99.5 97.5 95.8 N.A. 90.3 47.4 N.A. 80.1 75.9 80.3 34.1 N.A. N.A. 55.7 56 45.5
P-Site Identity: 100 100 100 73.3 N.A. 40 6.6 N.A. 40 20 6.6 13.3 N.A. N.A. 6.6 6.6 0
P-Site Similarity: 100 100 100 80 N.A. 53.3 20 N.A. 53.3 26.6 20 26.6 N.A. N.A. 6.6 13.3 13.3
Percent
Protein Identity: N.A. N.A. N.A. 28.8 27 N.A.
Protein Similarity: N.A. N.A. N.A. 44.5 47.1 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 7 27 0 7 0 20 7 40 0 7 0 7 7 % A
% Cys: 0 0 0 0 0 27 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 7 0 7 14 0 0 7 20 0 14 0 0 0 7 % D
% Glu: 0 0 7 0 7 7 0 0 0 7 7 0 7 7 0 % E
% Phe: 7 0 7 0 0 0 0 7 0 7 0 0 7 0 0 % F
% Gly: 0 0 7 7 7 7 0 0 0 0 0 7 0 7 7 % G
% His: 0 0 0 0 14 0 7 0 0 0 0 7 0 0 7 % H
% Ile: 0 0 7 0 7 0 7 14 0 0 0 0 7 0 7 % I
% Lys: 7 0 0 7 0 0 0 7 0 14 7 47 7 40 14 % K
% Leu: 40 0 7 7 27 7 7 7 0 0 20 0 47 0 0 % L
% Met: 0 0 0 0 0 0 0 0 14 0 0 0 0 14 0 % M
% Asn: 0 0 0 0 0 14 14 0 0 27 27 0 7 7 40 % N
% Pro: 7 20 40 0 7 7 0 7 20 0 7 0 0 7 7 % P
% Gln: 7 7 0 0 0 7 7 0 7 0 7 0 7 0 0 % Q
% Arg: 0 0 0 7 0 14 40 7 7 0 7 14 0 0 7 % R
% Ser: 0 14 14 14 0 7 0 0 7 0 0 14 14 7 0 % S
% Thr: 14 40 0 7 14 0 7 27 7 0 0 0 0 0 0 % T
% Val: 14 7 7 14 7 0 14 0 14 7 7 0 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 7 0 0 0 0 0 0 0 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _