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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MELK
All Species:
16.67
Human Site:
T446
Identified Species:
26.19
UniProt:
Q14680
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14680
NP_055606.1
651
74642
T446
F
M
F
P
E
P
K
T
P
V
N
K
N
Q
H
Chimpanzee
Pan troglodytes
XP_001168921
651
74605
T446
F
M
F
P
E
P
K
T
P
V
N
K
N
Q
H
Rhesus Macaque
Macaca mulatta
XP_001115076
651
74642
T446
F
M
F
P
E
P
K
T
P
V
N
K
N
Q
H
Dog
Lupus familis
XP_538730
651
74149
T446
F
V
F
P
E
P
K
T
P
V
N
K
S
Q
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q61846
643
72695
I438
F
V
F
S
E
P
K
I
P
V
S
K
N
Q
Y
Rat
Rattus norvegicus
P54645
559
63955
P370
D
D
H
H
L
T
R
P
H
P
E
R
V
P
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509217
655
73776
T450
F
M
L
P
A
P
K
T
P
V
T
K
K
L
N
Chicken
Gallus gallus
NP_001026680
657
74208
P452
L
P
F
A
L
P
A
P
K
A
S
F
S
K
S
Frog
Xenopus laevis
NP_001081569
651
74289
A446
E
N
V
F
L
H
P
A
P
W
T
P
T
P
R
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
P703
R
I
Q
P
S
S
P
P
P
T
H
P
S
N
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395000
606
68302
K417
P
I
K
R
T
A
E
K
D
K
F
V
S
T
P
Nematode Worm
Caenorhab. elegans
NP_001023420
703
79966
V499
G
P
L
K
I
T
G
V
E
E
G
T
M
K
S
Sea Urchin
Strong. purpuratus
XP_781767
971
109658
Q766
D
A
K
E
K
A
S
Q
K
A
R
G
A
A
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q2V452
441
50581
D251
K
L
I
T
R
I
L
D
P
N
P
M
T
R
V
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
A438
H
E
T
A
K
Q
H
A
R
R
M
A
S
A
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96.4
91.7
N.A.
83.4
29.6
N.A.
70.8
61.7
66.2
20.2
N.A.
N.A.
39.9
37.9
32.7
Protein Similarity:
100
99.5
97.5
95.8
N.A.
90.3
47.4
N.A.
80.1
75.9
80.3
34.1
N.A.
N.A.
55.7
56
45.5
P-Site Identity:
100
100
100
80
N.A.
66.6
0
N.A.
60
13.3
6.6
20
N.A.
N.A.
0
0
0
P-Site Similarity:
100
100
100
100
N.A.
86.6
13.3
N.A.
66.6
33.3
6.6
40
N.A.
N.A.
20
6.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.8
27
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.5
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
14
7
14
7
14
0
14
0
7
7
14
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
14
7
0
0
0
0
0
7
7
0
0
0
0
0
0
% D
% Glu:
7
7
0
7
34
0
7
0
7
7
7
0
0
0
0
% E
% Phe:
40
0
40
7
0
0
0
0
0
0
7
7
0
0
7
% F
% Gly:
7
0
0
0
0
0
7
0
0
0
7
7
0
0
0
% G
% His:
7
0
7
7
0
7
7
0
7
0
7
0
0
0
27
% H
% Ile:
0
14
7
0
7
7
0
7
0
0
0
0
0
0
7
% I
% Lys:
7
0
14
7
14
0
40
7
14
7
0
40
7
14
0
% K
% Leu:
7
7
14
0
20
0
7
0
0
0
0
0
0
7
7
% L
% Met:
0
27
0
0
0
0
0
0
0
0
7
7
7
0
0
% M
% Asn:
0
7
0
0
0
0
0
0
0
7
27
0
27
7
7
% N
% Pro:
7
14
0
40
0
47
14
20
60
7
7
14
0
14
7
% P
% Gln:
0
0
7
0
0
7
0
7
0
0
0
0
0
34
0
% Q
% Arg:
7
0
0
7
7
0
7
0
7
7
7
7
0
7
7
% R
% Ser:
0
0
0
7
7
7
7
0
0
0
14
0
34
0
14
% S
% Thr:
0
0
7
7
7
14
0
34
0
7
14
7
14
7
0
% T
% Val:
0
14
7
0
0
0
0
7
0
40
0
7
7
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
14
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _