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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MELK All Species: 16.67
Human Site: T494 Identified Species: 26.19
UniProt: Q14680 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14680 NP_055606.1 651 74642 T494 T G T D K L M T G V I S P E R
Chimpanzee Pan troglodytes XP_001168921 651 74605 T494 T G T D K L M T G V I S P E R
Rhesus Macaque Macaca mulatta XP_001115076 651 74642 T494 T G T D K L M T G V I S P E R
Dog Lupus familis XP_538730 651 74149 T494 A G T E K L M T G V I S P E R
Cat Felis silvestris
Mouse Mus musculus Q61846 643 72695 T486 A G A D T L T T G V I S P E R
Rat Rattus norvegicus P54645 559 63955 N418 I R S Q S R P N D I M A E V C
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509217 655 73776 G498 D I S T D L V G A A I S P E R
Chicken Gallus gallus NP_001026680 657 74208 A500 T N T C E L T A T E V L P E K
Frog Xenopus laevis NP_001081569 651 74289 A494 I G T G E E F A N V I S P E R
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 P751 G S A L Y Q S P S D S P P P T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_395000 606 68302 R465 R Y V L T P K R R V K N E N I
Nematode Worm Caenorhab. elegans NP_001023420 703 79966 G547 A S I G M P P G S P V S I G S
Sea Urchin Strong. purpuratus XP_781767 971 109658 Q814 S T G A F D I Q K A V S M E D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q2V452 441 50581 H299 V F K D S E E H L V T E K R E
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 G486 R A N M L A Q G S P A A S K I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 96.4 91.7 N.A. 83.4 29.6 N.A. 70.8 61.7 66.2 20.2 N.A. N.A. 39.9 37.9 32.7
Protein Similarity: 100 99.5 97.5 95.8 N.A. 90.3 47.4 N.A. 80.1 75.9 80.3 34.1 N.A. N.A. 55.7 56 45.5
P-Site Identity: 100 100 100 86.6 N.A. 73.3 0 N.A. 40 33.3 53.3 6.6 N.A. N.A. 6.6 6.6 13.3
P-Site Similarity: 100 100 100 93.3 N.A. 73.3 26.6 N.A. 53.3 53.3 60 6.6 N.A. N.A. 13.3 13.3 33.3
Percent
Protein Identity: N.A. N.A. N.A. 28.8 27 N.A.
Protein Similarity: N.A. N.A. N.A. 44.5 47.1 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 20 7 14 7 0 7 0 14 7 14 7 14 0 0 0 % A
% Cys: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 7 % C
% Asp: 7 0 0 34 7 7 0 0 7 7 0 0 0 0 7 % D
% Glu: 0 0 0 7 14 14 7 0 0 7 0 7 14 60 7 % E
% Phe: 0 7 0 0 7 0 7 0 0 0 0 0 0 0 0 % F
% Gly: 7 40 7 14 0 0 0 20 34 0 0 0 0 7 0 % G
% His: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % H
% Ile: 14 7 7 0 0 0 7 0 0 7 47 0 7 0 14 % I
% Lys: 0 0 7 0 27 0 7 0 7 0 7 0 7 7 7 % K
% Leu: 0 0 0 14 7 47 0 0 7 0 0 7 0 0 0 % L
% Met: 0 0 0 7 7 0 27 0 0 0 7 0 7 0 0 % M
% Asn: 0 7 7 0 0 0 0 7 7 0 0 7 0 7 0 % N
% Pro: 0 0 0 0 0 14 14 7 0 14 0 7 60 7 0 % P
% Gln: 0 0 0 7 0 7 7 7 0 0 0 0 0 0 0 % Q
% Arg: 14 7 0 0 0 7 0 7 7 0 0 0 0 7 47 % R
% Ser: 7 14 14 0 14 0 7 0 20 0 7 60 7 0 7 % S
% Thr: 27 7 40 7 14 0 14 34 7 0 7 0 0 0 7 % T
% Val: 7 0 7 0 0 0 7 0 0 54 20 0 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 0 0 7 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _