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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MELK All Species: 22.12
Human Site: T518 Identified Species: 34.76
UniProt: Q14680 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14680 NP_055606.1 651 74642 T518 N Q A H M E E T P K R K G A K
Chimpanzee Pan troglodytes XP_001168921 651 74605 T518 N Q A H M E E T P K R K G A K
Rhesus Macaque Macaca mulatta XP_001115076 651 74642 T518 N Q A H M E E T P K R K G A K
Dog Lupus familis XP_538730 651 74149 T518 N Q A H V E D T P K R K G T K
Cat Felis silvestris
Mouse Mus musculus Q61846 643 72695 T510 N Q A H M E D T P K K K G T N
Rat Rattus norvegicus P54645 559 63955 Y442 W K V V N P Y Y L R V R R K N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509217 655 73776 A522 N Q A H M E S A Q K K K G T G
Chicken Gallus gallus NP_001026680 657 74208 S524 N R G H V D S S Q K K R K A K
Frog Xenopus laevis NP_001081569 651 74289 A518 N Q A H I D S A Q K K K G A K
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 G775 Q Q P S V P P G S A R T L A Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_395000 606 68302 S489 G K G L C N V S S T S S D D P
Nematode Worm Caenorhab. elegans NP_001023420 703 79966 K571 R T P R S R I K T N R L P Q R
Sea Urchin Strong. purpuratus XP_781767 971 109658 I838 G D I K R H G I S G S A K K I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q2V452 441 50581 G323 E I I S M S R G L N L E N L F
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 R510 T R W H F G I R S R S Y P L D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 96.4 91.7 N.A. 83.4 29.6 N.A. 70.8 61.7 66.2 20.2 N.A. N.A. 39.9 37.9 32.7
Protein Similarity: 100 99.5 97.5 95.8 N.A. 90.3 47.4 N.A. 80.1 75.9 80.3 34.1 N.A. N.A. 55.7 56 45.5
P-Site Identity: 100 100 100 80 N.A. 73.3 0 N.A. 60 33.3 60 20 N.A. N.A. 0 6.6 0
P-Site Similarity: 100 100 100 93.3 N.A. 86.6 20 N.A. 66.6 73.3 80 33.3 N.A. N.A. 13.3 13.3 0
Percent
Protein Identity: N.A. N.A. N.A. 28.8 27 N.A.
Protein Similarity: N.A. N.A. N.A. 44.5 47.1 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 47 0 0 0 0 14 0 7 0 7 0 40 0 % A
% Cys: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 7 0 0 0 14 14 0 0 0 0 0 7 7 7 % D
% Glu: 7 0 0 0 0 40 20 0 0 0 0 7 0 0 0 % E
% Phe: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 7 % F
% Gly: 14 0 14 0 0 7 7 14 0 7 0 0 47 0 7 % G
% His: 0 0 0 60 0 7 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 7 14 0 7 0 14 7 0 0 0 0 0 0 7 % I
% Lys: 0 14 0 7 0 0 0 7 0 54 27 47 14 14 40 % K
% Leu: 0 0 0 7 0 0 0 0 14 0 7 7 7 14 0 % L
% Met: 0 0 0 0 40 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 54 0 0 0 7 7 0 0 0 14 0 0 7 0 14 % N
% Pro: 0 0 14 0 0 14 7 0 34 0 0 0 14 0 7 % P
% Gln: 7 54 0 0 0 0 0 0 20 0 0 0 0 7 7 % Q
% Arg: 7 14 0 7 7 7 7 7 0 14 40 14 7 0 7 % R
% Ser: 0 0 0 14 7 7 20 14 27 0 20 7 0 0 0 % S
% Thr: 7 7 0 0 0 0 0 34 7 7 0 7 0 20 0 % T
% Val: 0 0 7 7 20 0 7 0 0 0 7 0 0 0 0 % V
% Trp: 7 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 7 7 0 0 0 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _