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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MELK All Species: 9.39
Human Site: Y367 Identified Species: 14.76
UniProt: Q14680 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14680 NP_055606.1 651 74642 Y367 V T A S D K N Y V A G L I D Y
Chimpanzee Pan troglodytes XP_001168921 651 74605 Y367 V T A S D K N Y V A G L I D Y
Rhesus Macaque Macaca mulatta XP_001115076 651 74642 Y367 V T T S D E N Y V T G L I D Y
Dog Lupus familis XP_538730 651 74149 C367 M T T S D E N C V A G L I D Y
Cat Felis silvestris
Mouse Mus musculus Q61846 643 72695 S359 S L E D M S T S D D N C V A G
Rat Rattus norvegicus P54645 559 63955 D291 P K Y L F P E D P S Y S S T M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509217 655 73776 Q371 S L E V G S V Q C P G K D E L
Chicken Gallus gallus NP_001026680 657 74208 G373 S D V P D A F G S M E F S D A
Frog Xenopus laevis NP_001081569 651 74289 A367 E E P N G E I A Y V F G S M D
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 N624 A Y K T Q L E N N S L I R Q L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_395000 606 68302 S338 R I S S S A K S H F K S E Y E
Nematode Worm Caenorhab. elegans NP_001023420 703 79966 M420 A A E K D K K M S Y V N A M L
Sea Urchin Strong. purpuratus XP_781767 971 109658 R687 E R R H S G D R R R P R S S Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q2V452 441 50581 H172 V R D D G L L H T S C G T P N
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 E359 L S S T M G Y E K D E I Y E S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 96.4 91.7 N.A. 83.4 29.6 N.A. 70.8 61.7 66.2 20.2 N.A. N.A. 39.9 37.9 32.7
Protein Similarity: 100 99.5 97.5 95.8 N.A. 90.3 47.4 N.A. 80.1 75.9 80.3 34.1 N.A. N.A. 55.7 56 45.5
P-Site Identity: 100 100 80 73.3 N.A. 0 0 N.A. 6.6 13.3 0 0 N.A. N.A. 6.6 13.3 0
P-Site Similarity: 100 100 86.6 86.6 N.A. 6.6 6.6 N.A. 13.3 13.3 13.3 20 N.A. N.A. 13.3 13.3 6.6
Percent
Protein Identity: N.A. N.A. N.A. 28.8 27 N.A.
Protein Similarity: N.A. N.A. N.A. 44.5 47.1 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 14 7 14 0 0 14 0 7 0 20 0 0 7 7 7 % A
% Cys: 0 0 0 0 0 0 0 7 7 0 7 7 0 0 0 % C
% Asp: 0 7 7 14 40 0 7 7 7 14 0 0 7 34 7 % D
% Glu: 14 7 20 0 0 20 14 7 0 0 14 0 7 14 7 % E
% Phe: 0 0 0 0 7 0 7 0 0 7 7 7 0 0 0 % F
% Gly: 0 0 0 0 20 14 0 7 0 0 34 14 0 0 7 % G
% His: 0 0 0 7 0 0 0 7 7 0 0 0 0 0 0 % H
% Ile: 0 7 0 0 0 0 7 0 0 0 0 14 27 0 0 % I
% Lys: 0 7 7 7 0 20 14 0 7 0 7 7 0 0 0 % K
% Leu: 7 14 0 7 0 14 7 0 0 0 7 27 0 0 20 % L
% Met: 7 0 0 0 14 0 0 7 0 7 0 0 0 14 7 % M
% Asn: 0 0 0 7 0 0 27 7 7 0 7 7 0 0 7 % N
% Pro: 7 0 7 7 0 7 0 0 7 7 7 0 0 7 0 % P
% Gln: 0 0 0 0 7 0 0 7 0 0 0 0 0 7 7 % Q
% Arg: 7 14 7 0 0 0 0 7 7 7 0 7 7 0 0 % R
% Ser: 20 7 14 34 14 14 0 14 14 20 0 14 27 7 7 % S
% Thr: 0 27 14 14 0 0 7 0 7 7 0 0 7 7 0 % T
% Val: 27 0 7 7 0 0 7 0 27 7 7 0 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 7 0 0 0 7 20 7 7 7 0 7 7 27 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _