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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MELK All Species: 9.7
Human Site: Y396 Identified Species: 15.24
UniProt: Q14680 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14680 NP_055606.1 651 74642 Y396 R T S Q F T K Y W T E S N G V
Chimpanzee Pan troglodytes XP_001168921 651 74605 Y396 R T S Q F T K Y W T E S N G V
Rhesus Macaque Macaca mulatta XP_001115076 651 74642 Y396 Q K S Q F T K Y W T E S N G V
Dog Lupus familis XP_538730 651 74149 H396 Q T P Q F A K H W T E S N G L
Cat Felis silvestris
Mouse Mus musculus Q61846 643 72695 H388 K T P Q V T K H L A E S N H A
Rat Rattus norvegicus P54645 559 63955 S320 C S E E E V L S C L Y N R N H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509217 655 73776 H400 P K T E L A K H Q T E S L G A
Chicken Gallus gallus NP_001026680 657 74208 H402 N T H R T K Q H S R H D T Q L
Frog Xenopus laevis NP_001081569 651 74289 K396 S F E P H T P K E Y V K G R L
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 H653 Q D E R L M E H T Q Q Q H V L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_395000 606 68302 P367 R S K S V R S P I I D T T F K
Nematode Worm Caenorhab. elegans NP_001023420 703 79966 R449 P E S P M S V R S S D S A S L
Sea Urchin Strong. purpuratus XP_781767 971 109658 L716 Y V K P G D L L G E D T Y M V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q2V452 441 50581 C201 A T A D M W S C G V V L Y V L
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 E388 D A Y M L I K E N K S L I K D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 96.4 91.7 N.A. 83.4 29.6 N.A. 70.8 61.7 66.2 20.2 N.A. N.A. 39.9 37.9 32.7
Protein Similarity: 100 99.5 97.5 95.8 N.A. 90.3 47.4 N.A. 80.1 75.9 80.3 34.1 N.A. N.A. 55.7 56 45.5
P-Site Identity: 100 100 86.6 66.6 N.A. 46.6 0 N.A. 33.3 6.6 6.6 0 N.A. N.A. 6.6 13.3 6.6
P-Site Similarity: 100 100 93.3 86.6 N.A. 60 20 N.A. 53.3 33.3 13.3 46.6 N.A. N.A. 26.6 40 20
Percent
Protein Identity: N.A. N.A. N.A. 28.8 27 N.A.
Protein Similarity: N.A. N.A. N.A. 44.5 47.1 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 7 0 0 14 0 0 0 7 0 0 7 0 14 % A
% Cys: 7 0 0 0 0 0 0 7 7 0 0 0 0 0 0 % C
% Asp: 7 7 0 7 0 7 0 0 0 0 20 7 0 0 7 % D
% Glu: 0 7 20 14 7 0 7 7 7 7 40 0 0 0 0 % E
% Phe: 0 7 0 0 27 0 0 0 0 0 0 0 0 7 0 % F
% Gly: 0 0 0 0 7 0 0 0 14 0 0 0 7 34 0 % G
% His: 0 0 7 0 7 0 0 34 0 0 7 0 7 7 7 % H
% Ile: 0 0 0 0 0 7 0 0 7 7 0 0 7 0 0 % I
% Lys: 7 14 14 0 0 7 47 7 0 7 0 7 0 7 7 % K
% Leu: 0 0 0 0 20 0 14 7 7 7 0 14 7 0 40 % L
% Met: 0 0 0 7 14 7 0 0 0 0 0 0 0 7 0 % M
% Asn: 7 0 0 0 0 0 0 0 7 0 0 7 34 7 0 % N
% Pro: 14 0 14 20 0 0 7 7 0 0 0 0 0 0 0 % P
% Gln: 20 0 0 34 0 0 7 0 7 7 7 7 0 7 0 % Q
% Arg: 20 0 0 14 0 7 0 7 0 7 0 0 7 7 0 % R
% Ser: 7 14 27 7 0 7 14 7 14 7 7 47 0 7 0 % S
% Thr: 0 40 7 0 7 34 0 0 7 34 0 14 14 0 0 % T
% Val: 0 7 0 0 14 7 7 0 0 7 14 0 0 14 27 % V
% Trp: 0 0 0 0 0 7 0 0 27 0 0 0 0 0 0 % W
% Tyr: 7 0 7 0 0 0 0 20 0 7 7 0 14 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _