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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MELK All Species: 25.45
Human Site: Y561 Identified Species: 40
UniProt: Q14680 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14680 NP_055606.1 651 74642 Y561 P R R L K L H Y N V T T T R L
Chimpanzee Pan troglodytes XP_001168921 651 74605 Y561 P R R L K L H Y N V T T T R L
Rhesus Macaque Macaca mulatta XP_001115076 651 74642 I561 P R R L K F I I N I V L T E P
Dog Lupus familis XP_538730 651 74149 Y561 P R R L K L H Y N V T T T R L
Cat Felis silvestris
Mouse Mus musculus Q61846 643 72695 Y553 P R K R K L H Y N V T T T R L
Rat Rattus norvegicus P54645 559 63955 K485 D D E I T E A K S G T A T P Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509217 655 73776 Y565 P R R L R A H Y N V T T T K L
Chicken Gallus gallus NP_001026680 657 74208 Y567 P R K L K A H Y N V T M T Q L
Frog Xenopus laevis NP_001081569 651 74289 Y561 P R K L R A H Y N V T T T N I
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 K818 P C H R V L G K Q L S A D N A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_395000 606 68302 D532 T E D C T E D D K D A M R P F
Nematode Worm Caenorhab. elegans NP_001023420 703 79966 V614 L K D V K N M V N V S M T A S
Sea Urchin Strong. purpuratus XP_781767 971 109658 N881 R K V K A L Y N V S T T S T L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q2V452 441 50581 V366 A K P L G F D V Q K K N Y K M
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 G553 L R W K Y D I G N K T N T N E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 96.4 91.7 N.A. 83.4 29.6 N.A. 70.8 61.7 66.2 20.2 N.A. N.A. 39.9 37.9 32.7
Protein Similarity: 100 99.5 97.5 95.8 N.A. 90.3 47.4 N.A. 80.1 75.9 80.3 34.1 N.A. N.A. 55.7 56 45.5
P-Site Identity: 100 100 46.6 100 N.A. 86.6 13.3 N.A. 80 73.3 66.6 13.3 N.A. N.A. 0 26.6 26.6
P-Site Similarity: 100 100 53.3 100 N.A. 93.3 26.6 N.A. 93.3 86.6 86.6 26.6 N.A. N.A. 0 46.6 46.6
Percent
Protein Identity: N.A. N.A. N.A. 28.8 27 N.A.
Protein Similarity: N.A. N.A. N.A. 44.5 47.1 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 7 20 7 0 0 0 7 14 0 7 7 % A
% Cys: 0 7 0 7 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 7 14 0 0 7 14 7 0 7 0 0 7 0 0 % D
% Glu: 0 7 7 0 0 14 0 0 0 0 0 0 0 7 7 % E
% Phe: 0 0 0 0 0 14 0 0 0 0 0 0 0 0 7 % F
% Gly: 0 0 0 0 7 0 7 7 0 7 0 0 0 0 0 % G
% His: 0 0 7 0 0 0 47 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 7 0 0 14 7 0 7 0 0 0 0 7 % I
% Lys: 0 20 20 14 47 0 0 14 7 14 7 0 0 14 0 % K
% Leu: 14 0 0 54 0 40 0 0 0 7 0 7 0 0 47 % L
% Met: 0 0 0 0 0 0 7 0 0 0 0 20 0 0 7 % M
% Asn: 0 0 0 0 0 7 0 7 67 0 0 14 0 20 0 % N
% Pro: 60 0 7 0 0 0 0 0 0 0 0 0 0 14 7 % P
% Gln: 0 0 0 0 0 0 0 0 14 0 0 0 0 7 7 % Q
% Arg: 7 60 34 14 14 0 0 0 0 0 0 0 7 27 0 % R
% Ser: 0 0 0 0 0 0 0 0 7 7 14 0 7 0 7 % S
% Thr: 7 0 0 0 14 0 0 0 0 0 67 47 74 7 0 % T
% Val: 0 0 7 7 7 0 0 14 7 54 7 0 0 0 0 % V
% Trp: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 0 7 47 0 0 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _