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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC1A
All Species:
18.18
Human Site:
S244
Identified Species:
26.67
UniProt:
Q14683
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14683
NP_006297.2
1233
143233
S244
K
L
N
K
E
L
A
S
K
N
K
E
I
E
K
Chimpanzee
Pan troglodytes
XP_515195
1235
143766
H244
L
L
N
T
K
L
E
H
V
N
R
D
L
S
V
Rhesus Macaque
Macaca mulatta
XP_001091228
1196
139006
S244
K
L
N
K
E
L
A
S
K
N
K
E
I
E
K
Dog
Lupus familis
XP_538049
1295
149661
S306
K
L
N
K
E
L
A
S
K
N
K
E
I
E
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9CU62
1233
143197
S244
K
L
N
K
E
L
A
S
K
N
K
E
I
E
K
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
S244
K
L
N
K
E
L
A
S
K
N
K
E
I
E
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511311
1329
152821
E215
L
L
S
M
Q
L
D
E
K
N
M
A
L
S
N
Chicken
Gallus gallus
Q90988
1189
134923
E269
K
I
F
E
S
M
A
E
N
E
K
K
V
K
E
Frog
Xenopus laevis
O93308
1232
142609
V244
K
L
N
K
E
L
S
V
K
N
K
G
I
E
K
Zebra Danio
Brachydanio rerio
NP_001155103
1232
143125
Q244
K
L
N
R
E
L
S
Q
R
N
R
E
I
D
K
Tiger Blowfish
Takifugu rubipres
NP_001027867
1245
142913
E244
V
L
S
G
T
L
R
E
K
Q
Q
A
A
G
E
Fruit Fly
Dros. melanogaster
NP_651211
1238
142862
V267
K
F
T
S
D
L
E
V
R
Q
Q
E
V
K
A
Honey Bee
Apis mellifera
XP_395059
1230
141414
K245
N
L
E
V
L
Q
K
K
K
Q
H
E
I
E
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786064
1247
143265
G244
R
L
S
D
E
L
G
G
R
N
E
D
L
K
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
K316
S
V
H
E
K
H
K
K
R
Q
E
V
L
D
N
Baker's Yeast
Sacchar. cerevisiae
P32908
1225
141262
A258
E
L
T
D
K
L
S
A
L
N
S
E
I
S
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
53.3
97
95.1
N.A.
99.4
99.5
N.A.
48.9
25.1
93.8
89.1
46.9
49
54.7
N.A.
62.7
Protein Similarity:
100
74.6
97
95.1
N.A.
99.8
99.6
N.A.
68.1
46.7
96.5
95.4
70.2
70.3
73.6
N.A.
79.9
P-Site Identity:
100
26.6
100
100
N.A.
100
100
N.A.
26.6
20
80
60
20
20
40
N.A.
26.6
P-Site Similarity:
100
53.3
100
100
N.A.
100
100
N.A.
46.6
66.6
86.6
93.3
40
53.3
40
N.A.
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.6
30.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.6
57
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
38
7
0
0
0
13
7
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
13
7
0
7
0
0
0
0
13
0
13
0
% D
% Glu:
7
0
7
13
50
0
13
19
0
7
13
57
0
44
13
% E
% Phe:
0
7
7
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
7
0
0
7
7
0
0
0
7
0
7
0
% G
% His:
0
0
7
0
0
7
0
7
0
0
7
0
0
0
0
% H
% Ile:
0
7
0
0
0
0
0
0
0
0
0
0
57
0
0
% I
% Lys:
57
0
0
38
19
0
13
13
57
0
44
7
0
19
50
% K
% Leu:
13
82
0
0
7
82
0
0
7
0
0
0
25
0
0
% L
% Met:
0
0
0
7
0
7
0
0
0
0
7
0
0
0
0
% M
% Asn:
7
0
50
0
0
0
0
0
7
69
0
0
0
0
13
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
7
7
0
7
0
25
13
0
0
0
0
% Q
% Arg:
7
0
0
7
0
0
7
0
25
0
13
0
0
0
7
% R
% Ser:
7
0
19
7
7
0
19
32
0
0
7
0
0
19
7
% S
% Thr:
0
0
13
7
7
0
0
0
0
0
0
0
0
0
0
% T
% Val:
7
7
0
7
0
0
0
13
7
0
0
7
13
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _