Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SMC1A All Species: 42.73
Human Site: S318 Identified Species: 62.67
UniProt: Q14683 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14683 NP_006297.2 1233 143233 S318 K L E A A K K S L Q N A Q K H
Chimpanzee Pan troglodytes XP_515195 1235 143766 S318 K L D V A K K S I K D S E K Q
Rhesus Macaque Macaca mulatta XP_001091228 1196 139006 S318 K L E A A K K S L Q N A Q K H
Dog Lupus familis XP_538049 1295 149661 S380 K L E A A K K S L Q N A Q K H
Cat Felis silvestris
Mouse Mus musculus Q9CU62 1233 143197 S318 K L E A A K K S L Q H A Q K H
Rat Rattus norvegicus Q9Z1M9 1233 143186 S318 K L E A A K K S L Q N R Q K H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511311 1329 152821 G289 K L E M E S E G I R E A E E Q
Chicken Gallus gallus Q90988 1189 134923 S315 R V D A K V R S D L D H R K Q
Frog Xenopus laevis O93308 1232 142609 S318 K F R A A K K S L Q N A Q K Q
Zebra Danio Brachydanio rerio NP_001155103 1232 143125 S318 K L E V A R K S L Q N A Q K M
Tiger Blowfish Takifugu rubipres NP_001027867 1245 142913 A318 K M E L A R D A L K K A E K T
Fruit Fly Dros. melanogaster NP_651211 1238 142862 T341 K L I S L Q K T L E T A R E A
Honey Bee Apis mellifera XP_395059 1230 141414 S319 K V E S A R K S L A Q A R I A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786064 1247 143265 S318 K L E N A K K S L K S A K K A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FJL0 1241 141112 K362 K L E D K L E K D S S K I G D
Baker's Yeast Sacchar. cerevisiae P32908 1225 141262 D339 R I E S L Q K D L Q R Q K T Y
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 53.3 97 95.1 N.A. 99.4 99.5 N.A. 48.9 25.1 93.8 89.1 46.9 49 54.7 N.A. 62.7
Protein Similarity: 100 74.6 97 95.1 N.A. 99.8 99.6 N.A. 68.1 46.7 96.5 95.4 70.2 70.3 73.6 N.A. 79.9
P-Site Identity: 100 46.6 100 100 N.A. 93.3 93.3 N.A. 26.6 20 80 80 40 33.3 46.6 N.A. 66.6
P-Site Similarity: 100 86.6 100 100 N.A. 100 93.3 N.A. 60 60 80 86.6 73.3 73.3 73.3 N.A. 86.6
Percent
Protein Identity: N.A. N.A. N.A. 23.6 30.9 N.A.
Protein Similarity: N.A. N.A. N.A. 48.6 57 N.A.
P-Site Identity: N.A. N.A. N.A. 20 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 66.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 44 69 0 0 7 0 7 0 69 0 0 19 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 13 7 0 0 7 7 13 0 13 0 0 0 7 % D
% Glu: 0 0 75 0 7 0 13 0 0 7 7 0 19 13 0 % E
% Phe: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 7 0 0 0 0 0 7 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 7 7 0 0 32 % H
% Ile: 0 7 7 0 0 0 0 0 13 0 0 0 7 7 0 % I
% Lys: 88 0 0 0 13 50 75 7 0 19 7 7 13 69 0 % K
% Leu: 0 69 0 7 13 7 0 0 75 7 0 0 0 0 0 % L
% Met: 0 7 0 7 0 0 0 0 0 0 0 0 0 0 7 % M
% Asn: 0 0 0 7 0 0 0 0 0 0 38 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 13 0 0 0 50 7 7 44 0 25 % Q
% Arg: 13 0 7 0 0 19 7 0 0 7 7 7 19 0 0 % R
% Ser: 0 0 0 19 0 7 0 69 0 7 13 7 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 7 0 0 7 0 0 7 7 % T
% Val: 0 13 0 13 0 7 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _