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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SMC1A All Species: 42.73
Human Site: S715 Identified Species: 62.67
UniProt: Q14683 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14683 NP_006297.2 1233 143233 S715 L Q M R L K Y S Q S D L E Q T
Chimpanzee Pan troglodytes XP_515195 1235 143766 S715 T Q T R L K Y S Q N E L E M I
Rhesus Macaque Macaca mulatta XP_001091228 1196 139006 S715 L Q M R L K Y S Q S D L E Q T
Dog Lupus familis XP_538049 1295 149661 S777 L Q M R L K Y S Q S D L E Q T
Cat Felis silvestris
Mouse Mus musculus Q9CU62 1233 143197 S715 L Q M R L K Y S Q S D L E Q T
Rat Rattus norvegicus Q9Z1M9 1233 143186 S715 L Q M R L K Y S Q S D L E Q T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511311 1329 152821 S686 T Q T R L R Y S Q G E L E T V
Chicken Gallus gallus Q90988 1189 134923 E724 Q Q W E M K S E E A E L L Q T
Frog Xenopus laevis O93308 1232 142609 S715 L Q M R L K Y S Q S D L E Q T
Zebra Danio Brachydanio rerio NP_001155103 1232 143125 S715 L Q M R L K Y S Q S D L E Q T
Tiger Blowfish Takifugu rubipres NP_001027867 1245 142913 A723 A K T R L K Y A K A D L D N I
Fruit Fly Dros. melanogaster NP_651211 1238 142862 S741 L E N R L K Y S M V D L E S S
Honey Bee Apis mellifera XP_395059 1230 141414 N720 L E T R L K Y N K S D L A A T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786064 1247 143265 S717 Q E T R L K Y S V N D R D N T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FJL0 1241 141112 S766 L E M E L A K S Q R E I E S L
Baker's Yeast Sacchar. cerevisiae P32908 1225 141262 N715 I R A R E V E N S V S L L N S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 53.3 97 95.1 N.A. 99.4 99.5 N.A. 48.9 25.1 93.8 89.1 46.9 49 54.7 N.A. 62.7
Protein Similarity: 100 74.6 97 95.1 N.A. 99.8 99.6 N.A. 68.1 46.7 96.5 95.4 70.2 70.3 73.6 N.A. 79.9
P-Site Identity: 100 60 100 100 N.A. 100 100 N.A. 53.3 33.3 100 100 40 60 60 N.A. 46.6
P-Site Similarity: 100 73.3 100 100 N.A. 100 100 N.A. 66.6 60 100 100 73.3 73.3 80 N.A. 66.6
Percent
Protein Identity: N.A. N.A. N.A. 23.6 30.9 N.A.
Protein Similarity: N.A. N.A. N.A. 48.6 57 N.A.
P-Site Identity: N.A. N.A. N.A. 40 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 60 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 7 0 0 7 0 7 0 13 0 0 7 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 69 0 13 0 0 % D
% Glu: 0 25 0 13 7 0 7 7 7 0 25 0 69 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 7 0 0 0 0 0 0 0 0 0 0 7 0 0 13 % I
% Lys: 0 7 0 0 0 82 7 0 13 0 0 0 0 0 0 % K
% Leu: 63 0 0 0 88 0 0 0 0 0 0 88 13 0 7 % L
% Met: 0 0 50 0 7 0 0 0 7 0 0 0 0 7 0 % M
% Asn: 0 0 7 0 0 0 0 13 0 13 0 0 0 19 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 13 63 0 0 0 0 0 0 63 0 0 0 0 50 0 % Q
% Arg: 0 7 0 88 0 7 0 0 0 7 0 7 0 0 0 % R
% Ser: 0 0 0 0 0 0 7 75 7 50 7 0 0 13 13 % S
% Thr: 13 0 32 0 0 0 0 0 0 0 0 0 0 7 63 % T
% Val: 0 0 0 0 0 7 0 0 7 13 0 0 0 0 7 % V
% Trp: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 82 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _