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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC1A
All Species:
38.18
Human Site:
T1221
Identified Species:
56
UniProt:
Q14683
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14683
NP_006297.2
1233
143233
T1221
K
V
L
T
F
D
L
T
K
Y
P
D
A
N
P
Chimpanzee
Pan troglodytes
XP_515195
1235
143766
S1217
R
V
L
T
L
D
L
S
Q
Y
P
D
T
E
G
Rhesus Macaque
Macaca mulatta
XP_001091228
1196
139006
T1184
K
V
L
T
F
D
L
T
K
Y
P
D
A
N
P
Dog
Lupus familis
XP_538049
1295
149661
T1283
K
V
L
T
F
D
L
T
K
Y
P
D
A
N
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9CU62
1233
143197
T1221
K
V
L
T
F
D
L
T
K
Y
P
D
A
N
P
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
T1221
K
V
L
T
F
D
L
T
K
Y
P
D
A
N
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511311
1329
152821
T1188
Q
M
L
T
L
D
L
T
L
Y
P
E
S
E
A
Chicken
Gallus gallus
Q90988
1189
134923
K1177
R
H
C
Q
L
K
K
K
Q
P
L
S
E
A
S
Frog
Xenopus laevis
O93308
1232
142609
T1221
K
V
L
T
F
D
L
T
K
Y
P
D
A
N
P
Zebra Danio
Brachydanio rerio
NP_001155103
1232
143125
S1221
K
V
L
T
F
D
L
S
Q
Y
P
D
A
N
P
Tiger Blowfish
Takifugu rubipres
NP_001027867
1245
142913
R1224
H
I
L
T
L
D
L
R
P
Y
P
L
A
E
E
Fruit Fly
Dros. melanogaster
NP_651211
1238
142862
G1218
A
L
V
G
I
T
P
G
E
G
D
C
L
V
S
Honey Bee
Apis mellifera
XP_395059
1230
141414
L1221
S
K
V
L
T
L
D
L
T
T
Y
P
T
H
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786064
1247
143265
T1231
R
V
L
T
L
D
L
T
E
Y
P
E
A
P
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
S1232
S
I
T
I
N
P
G
S
F
A
V
C
Q
K
T
Baker's Yeast
Sacchar. cerevisiae
P32908
1225
141262
I1215
Q
Q
E
N
S
S
K
I
I
T
L
D
L
S
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
53.3
97
95.1
N.A.
99.4
99.5
N.A.
48.9
25.1
93.8
89.1
46.9
49
54.7
N.A.
62.7
Protein Similarity:
100
74.6
97
95.1
N.A.
99.8
99.6
N.A.
68.1
46.7
96.5
95.4
70.2
70.3
73.6
N.A.
79.9
P-Site Identity:
100
53.3
100
100
N.A.
100
100
N.A.
46.6
0
100
86.6
46.6
0
0
N.A.
60
P-Site Similarity:
100
73.3
100
100
N.A.
100
100
N.A.
73.3
13.3
100
100
53.3
20
13.3
N.A.
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.6
30.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.6
57
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
0
0
0
0
7
0
0
57
7
13
% A
% Cys:
0
0
7
0
0
0
0
0
0
0
0
13
0
0
0
% C
% Asp:
0
0
0
0
0
69
7
0
0
0
7
57
0
0
0
% D
% Glu:
0
0
7
0
0
0
0
0
13
0
0
13
7
19
7
% E
% Phe:
0
0
0
0
44
0
0
0
7
0
0
0
0
0
0
% F
% Gly:
0
0
0
7
0
0
7
7
0
7
0
0
0
0
7
% G
% His:
7
7
0
0
0
0
0
0
0
0
0
0
0
7
0
% H
% Ile:
0
13
0
7
7
0
0
7
7
0
0
0
0
0
7
% I
% Lys:
44
7
0
0
0
7
13
7
38
0
0
0
0
7
0
% K
% Leu:
0
7
69
7
32
7
69
7
7
0
13
7
13
0
0
% L
% Met:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
7
7
0
0
0
0
0
0
0
0
44
7
% N
% Pro:
0
0
0
0
0
7
7
0
7
7
69
7
0
7
44
% P
% Gln:
13
7
0
7
0
0
0
0
19
0
0
0
7
0
0
% Q
% Arg:
19
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% R
% Ser:
13
0
0
0
7
7
0
19
0
0
0
7
7
7
13
% S
% Thr:
0
0
7
69
7
7
0
50
7
13
0
0
13
0
7
% T
% Val:
0
57
13
0
0
0
0
0
0
0
7
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
69
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _