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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC1A
All Species:
49.7
Human Site:
Y375
Identified Species:
72.89
UniProt:
Q14683
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14683
NP_006297.2
1233
143233
Y375
E
E
N
Q
V
K
K
Y
H
R
L
K
E
E
A
Chimpanzee
Pan troglodytes
XP_515195
1235
143766
Y375
E
A
S
Q
L
D
R
Y
K
E
L
K
E
Q
V
Rhesus Macaque
Macaca mulatta
XP_001091228
1196
139006
Y375
E
E
N
Q
V
K
K
Y
H
R
L
K
E
E
A
Dog
Lupus familis
XP_538049
1295
149661
Y437
E
E
N
Q
V
K
K
Y
H
R
L
K
E
E
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9CU62
1233
143197
Y375
E
E
N
Q
V
K
K
Y
H
R
L
K
E
E
A
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
Y375
E
E
N
Q
V
K
K
Y
H
R
L
K
E
E
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511311
1329
152821
Y346
E
S
N
Q
L
E
Q
Y
K
E
L
K
E
R
V
Chicken
Gallus gallus
Q90988
1189
134923
S375
K
D
A
E
A
L
A
S
A
Q
Q
H
F
N
A
Frog
Xenopus laevis
O93308
1232
142609
Y375
E
E
N
Q
V
K
K
Y
H
R
L
K
E
E
A
Zebra Danio
Brachydanio rerio
NP_001155103
1232
143125
Y375
E
E
N
Q
V
K
Q
Y
H
R
L
K
E
E
A
Tiger Blowfish
Takifugu rubipres
NP_001027867
1245
142913
Y375
D
E
D
Q
L
K
Q
Y
R
D
L
K
E
L
V
Fruit Fly
Dros. melanogaster
NP_651211
1238
142862
Y398
E
E
G
L
V
Q
E
Y
D
R
L
K
Q
E
A
Honey Bee
Apis mellifera
XP_395059
1230
141414
Y376
E
D
E
Q
V
R
E
Y
N
R
L
K
E
E
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786064
1247
143265
Y375
E
T
S
Q
V
T
E
Y
H
S
L
K
K
E
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
W430
I
R
A
E
L
E
P
W
E
K
D
L
I
V
H
Baker's Yeast
Sacchar. cerevisiae
P32908
1225
141262
G400
E
K
Y
L
T
E
G
G
S
I
L
E
E
K
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
53.3
97
95.1
N.A.
99.4
99.5
N.A.
48.9
25.1
93.8
89.1
46.9
49
54.7
N.A.
62.7
Protein Similarity:
100
74.6
97
95.1
N.A.
99.8
99.6
N.A.
68.1
46.7
96.5
95.4
70.2
70.3
73.6
N.A.
79.9
P-Site Identity:
100
40
100
100
N.A.
100
100
N.A.
46.6
6.6
100
93.3
46.6
60
66.6
N.A.
60
P-Site Similarity:
100
66.6
100
100
N.A.
100
100
N.A.
66.6
33.3
100
100
73.3
80
93.3
N.A.
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.6
30.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.6
57
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
13
0
7
0
7
0
7
0
0
0
0
0
69
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
13
7
0
0
7
0
0
7
7
7
0
0
0
0
% D
% Glu:
82
57
7
13
0
19
19
0
7
13
0
7
75
63
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% F
% Gly:
0
0
7
0
0
0
7
7
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
50
0
0
7
0
0
7
% H
% Ile:
7
0
0
0
0
0
0
0
0
7
0
0
7
0
7
% I
% Lys:
7
7
0
0
0
50
38
0
13
7
0
82
7
7
0
% K
% Leu:
0
0
0
13
25
7
0
0
0
0
88
7
0
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
50
0
0
0
0
0
7
0
0
0
0
7
0
% N
% Pro:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
75
0
7
19
0
0
7
7
0
7
7
0
% Q
% Arg:
0
7
0
0
0
7
7
0
7
57
0
0
0
7
0
% R
% Ser:
0
7
13
0
0
0
0
7
7
7
0
0
0
0
0
% S
% Thr:
0
7
0
0
7
7
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
63
0
0
0
0
0
0
0
0
7
19
% V
% Trp:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
0
0
82
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _