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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SMC1A All Species: 50.61
Human Site: Y575 Identified Species: 74.22
UniProt: Q14683 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14683 NP_006297.2 1233 143233 Y575 E T F L P L D Y L E V K P T D
Chimpanzee Pan troglodytes XP_515195 1235 143766 Y575 E T F L A L D Y L D I K P I N
Rhesus Macaque Macaca mulatta XP_001091228 1196 139006 Y575 E T F L P L D Y L E V K P T D
Dog Lupus familis XP_538049 1295 149661 Y637 E T F L P L D Y L E V K P T D
Cat Felis silvestris
Mouse Mus musculus Q9CU62 1233 143197 Y575 E T F L P L D Y L E V K P T D
Rat Rattus norvegicus Q9Z1M9 1233 143186 Y575 E T F L P L D Y L E V K P T D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511311 1329 152821 Y546 E T F L A L D Y L D I K P I N
Chicken Gallus gallus Q90988 1189 134923 S582 I I P L S K I S A N S I G H E
Frog Xenopus laevis O93308 1232 142609 Y575 E T F L P L D Y L E V K P T D
Zebra Danio Brachydanio rerio NP_001155103 1232 143125 Y575 E T F L P L D Y L E V K P T D
Tiger Blowfish Takifugu rubipres NP_001027867 1245 142913 Y579 E T F L P I D Y L D V S P L N
Fruit Fly Dros. melanogaster NP_651211 1238 142862 Y597 E T F L P L D Y L Q V K P L K
Honey Bee Apis mellifera XP_395059 1230 141414 Y575 E T F L P L D Y I Q A K P L K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786064 1247 143265 F574 E T F L P L D F I E V K P I N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FJL0 1241 141112 T617 F M I L E K Q T D H I H K L K
Baker's Yeast Sacchar. cerevisiae P32908 1225 141262 T589 A S F I P L D T I E T E L P T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 53.3 97 95.1 N.A. 99.4 99.5 N.A. 48.9 25.1 93.8 89.1 46.9 49 54.7 N.A. 62.7
Protein Similarity: 100 74.6 97 95.1 N.A. 99.8 99.6 N.A. 68.1 46.7 96.5 95.4 70.2 70.3 73.6 N.A. 79.9
P-Site Identity: 100 66.6 100 100 N.A. 100 100 N.A. 66.6 6.6 100 100 66.6 80 66.6 N.A. 73.3
P-Site Similarity: 100 86.6 100 100 N.A. 100 100 N.A. 86.6 13.3 100 100 86.6 86.6 80 N.A. 93.3
Percent
Protein Identity: N.A. N.A. N.A. 23.6 30.9 N.A.
Protein Similarity: N.A. N.A. N.A. 48.6 57 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 33.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 13 0 0 0 7 0 7 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 88 0 7 19 0 0 0 0 44 % D
% Glu: 82 0 0 0 7 0 0 0 0 57 0 7 0 0 7 % E
% Phe: 7 0 88 0 0 0 0 7 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 7 0 7 0 7 0 % H
% Ile: 7 7 7 7 0 7 7 0 19 0 19 7 0 19 0 % I
% Lys: 0 0 0 0 0 13 0 0 0 0 0 75 7 0 19 % K
% Leu: 0 0 0 94 0 82 0 0 69 0 0 0 7 25 0 % L
% Met: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 25 % N
% Pro: 0 0 7 0 75 0 0 0 0 0 0 0 82 7 0 % P
% Gln: 0 0 0 0 0 0 7 0 0 13 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 7 0 0 7 0 0 7 0 0 7 7 0 0 0 % S
% Thr: 0 82 0 0 0 0 0 13 0 0 7 0 0 44 7 % T
% Val: 0 0 0 0 0 0 0 0 0 0 63 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 75 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _