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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GINS1 All Species: 30.61
Human Site: Y81 Identified Species: 56.11
UniProt: Q14691 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14691 NP_066545.3 196 22988 Y81 R C T V A Y L Y D R L L R I R
Chimpanzee Pan troglodytes XP_001150442 157 18389 R55 N E A K S G G R S D L I P T I
Rhesus Macaque Macaca mulatta XP_001107106 260 30566 Y145 R C T V A Y L Y D R L L R I R
Dog Lupus familis XP_848652 196 22905 Y81 R C A V A Y L Y D R L L R I R
Cat Felis silvestris
Mouse Mus musculus Q9CZ15 196 22875 Y81 R C T I A Y L Y D R L L R I R
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519883 136 15929 R36 V T A Y L Y D R L L R I R A L
Chicken Gallus gallus NP_001012621 195 22763 Y80 R C I V A Y L Y D R L L R I R
Frog Xenopus laevis NP_001085502 196 23120 Y81 R C I V A Y L Y D R L L R I R
Zebra Danio Brachydanio rerio NP_001006081 196 23050 Y81 R C I A A Y L Y D R L L R I R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_395538 194 22509 Y79 R C I L A Y I Y N R M R K L R
Nematode Worm Caenorhab. elegans Q22019 201 22718 N88 R C M M A Y V N E R K N R I R
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q12488 208 24185 Y89 N K R C L L A Y Q R L R T D I
Red Bread Mold Neurospora crassa Q7SDH9 216 24135 R88 R C L L A Y H R I R T D K L E
Conservation
Percent
Protein Identity: 100 80 74.2 95.4 N.A. 93.3 N.A. N.A. 62.7 77 88.7 84.1 N.A. N.A. 44.9 38.8 N.A.
Protein Similarity: 100 80 75.3 98.9 N.A. 98.4 N.A. N.A. 66.8 89.2 96.4 93.8 N.A. N.A. 68.8 62.6 N.A.
P-Site Identity: 100 6.6 100 93.3 N.A. 93.3 N.A. N.A. 13.3 93.3 93.3 86.6 N.A. N.A. 46.6 53.3 N.A.
P-Site Similarity: 100 20 100 93.3 N.A. 100 N.A. N.A. 20 93.3 93.3 86.6 N.A. N.A. 86.6 73.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26.4 26.8
Protein Similarity: N.A. N.A. N.A. N.A. 50 46.7
P-Site Identity: N.A. N.A. N.A. N.A. 20 33.3
P-Site Similarity: N.A. N.A. N.A. N.A. 20 53.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 24 8 77 0 8 0 0 0 0 0 0 8 0 % A
% Cys: 0 77 0 8 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 8 0 54 8 0 8 0 8 0 % D
% Glu: 0 8 0 0 0 0 0 0 8 0 0 0 0 0 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 8 8 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 31 8 0 0 8 0 8 0 0 16 0 62 16 % I
% Lys: 0 8 0 8 0 0 0 0 0 0 8 0 16 0 0 % K
% Leu: 0 0 8 16 16 8 54 0 8 8 70 54 0 16 8 % L
% Met: 0 0 8 8 0 0 0 0 0 0 8 0 0 0 0 % M
% Asn: 16 0 0 0 0 0 0 8 8 0 0 8 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % Q
% Arg: 77 0 8 0 0 0 0 24 0 85 8 16 70 0 70 % R
% Ser: 0 0 0 0 8 0 0 0 8 0 0 0 0 0 0 % S
% Thr: 0 8 24 0 0 0 0 0 0 0 8 0 8 8 0 % T
% Val: 8 0 0 39 0 0 8 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 0 85 0 70 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _