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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MESDC2
All Species:
3.33
Human Site:
S221
Identified Species:
5.64
UniProt:
Q14696
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14696
NP_055969.1
234
26077
S221
G
D
L
K
S
R
S
S
K
E
E
N
R
A
G
Chimpanzee
Pan troglodytes
XP_001161202
85
9478
A78
S
S
K
E
E
N
Q
A
G
N
K
R
E
D
L
Rhesus Macaque
Macaca mulatta
XP_001109767
149
16578
N142
L
W
Q
G
S
L
F
N
A
N
Y
D
V
Q
R
Dog
Lupus familis
XP_545883
190
21252
A183
V
V
Q
E
D
N
R
A
G
N
K
R
E
E
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERE7
224
25188
K212
D
P
K
P
R
A
S
K
E
D
N
R
A
G
S
Rat
Rattus norvegicus
Q5U2R7
224
25197
K212
D
P
K
P
R
A
S
K
E
D
N
R
A
G
S
Wallaby
Macropus eugenll
Q9XT48
201
21518
V194
L
L
Q
S
P
S
S
V
F
F
G
A
F
A
L
Platypus
Ornith. anatinus
XP_001514817
161
18036
A154
S
S
K
E
S
N
S
A
A
R
Q
R
E
D
L
Chicken
Gallus gallus
Q5ZKK4
220
24673
S205
K
D
A
E
K
S
K
S
S
H
E
D
N
R
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A1L243
206
23288
A199
D
K
K
A
A
N
R
A
N
K
G
K
Q
E
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q8T9B6
180
20983
V173
E
N
K
E
Y
P
G
V
N
A
K
K
D
E
L
Honey Bee
Apis mellifera
XP_001122588
178
21016
Y171
V
T
L
E
G
Q
T
Y
F
R
D
P
K
K
Q
Nematode Worm
Caenorhab. elegans
NP_495003
186
21786
F179
F
D
G
P
A
K
K
F
K
T
G
K
K
E
L
Sea Urchin
Strong. purpuratus
XP_001188878
182
21140
E175
K
K
K
E
T
K
I
E
N
N
K
T
E
F
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.9
61.1
67.5
N.A.
83.7
81.6
21.3
59.4
74.3
N.A.
64
N.A.
38.8
30.3
34.6
38.4
Protein Similarity:
100
36.3
62.8
73.5
N.A.
90.5
88.8
35.4
64
80.3
N.A.
73.9
N.A.
56.4
49.5
52.1
53.8
P-Site Identity:
100
0
6.6
0
N.A.
6.6
6.6
13.3
13.3
20
N.A.
0
N.A.
0
6.6
13.3
0
P-Site Similarity:
100
20
20
20
N.A.
20
20
13.3
33.3
33.3
N.A.
26.6
N.A.
20
40
33.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
15
15
0
29
15
8
0
8
15
15
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
22
22
0
0
8
0
0
0
0
15
8
15
8
15
0
% D
% Glu:
8
0
0
50
8
0
0
8
15
8
15
0
29
29
0
% E
% Phe:
8
0
0
0
0
0
8
8
15
8
0
0
8
8
0
% F
% Gly:
8
0
8
8
8
0
8
0
15
0
22
0
0
15
8
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% I
% Lys:
15
15
50
8
8
15
15
15
15
8
29
22
15
8
0
% K
% Leu:
15
8
15
0
0
8
0
0
0
0
0
0
0
0
50
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
29
0
8
22
29
15
8
8
0
0
% N
% Pro:
0
15
0
22
8
8
0
0
0
0
0
8
0
0
0
% P
% Gln:
0
0
22
0
0
8
8
0
0
0
8
0
8
8
8
% Q
% Arg:
0
0
0
0
15
8
15
0
0
15
0
36
8
8
8
% R
% Ser:
15
15
0
8
22
15
36
15
8
0
0
0
0
0
15
% S
% Thr:
0
8
0
0
8
0
8
0
0
8
0
8
0
0
0
% T
% Val:
15
8
0
0
0
0
0
15
0
0
0
0
8
0
8
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
8
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _