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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GANAB All Species: 16.97
Human Site: S458 Identified Species: 33.94
UniProt: Q14697 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14697 NP_938148.1 944 106874 S458 T M L E R L A S K R R K L V A
Chimpanzee Pan troglodytes XP_001154003 944 106938 S458 T M L E R L A S K R R K L V A
Rhesus Macaque Macaca mulatta XP_001116402 944 106915 S458 T M L E R L A S K R R K L V A
Dog Lupus familis XP_540905 966 108897 S480 T M L Q H L A S K R R K L V T
Cat Felis silvestris
Mouse Mus musculus Q8BHN3 944 106893 S458 N M L E H L A S K R R K L V A
Rat Rattus norvegicus Q6P7A9 953 106188 Q433 D M V H E L H Q G G R R Y M M
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_421156 914 104814 K427 K M Q E L L R K K K R K L V V
Frog Xenopus laevis NP_001091232 933 106071 E448 D M L S G L K E K R R K M V A
Zebra Danio Brachydanio rerio XP_002664506 941 106759 D451 E M L Q G L M D K R R K M V A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623603 925 106819 A437 E M I H N L T A K G R K L V V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9S7Y7 915 102380 F428 W G D E I K R F H D L V P I D
Baker's Yeast Sacchar. cerevisiae P38138 954 110248 K454 R L L S K L K K L G R N L V V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 98.6 90.9 N.A. 92 28.1 N.A. N.A. 50.8 68.9 65 N.A. N.A. 49 N.A. N.A.
Protein Similarity: 100 99.6 99.3 95 N.A. 96.7 43.9 N.A. N.A. 68.3 80.8 79.9 N.A. N.A. 66.2 N.A. N.A.
P-Site Identity: 100 100 100 80 N.A. 86.6 20 N.A. N.A. 53.3 60 60 N.A. N.A. 46.6 N.A. N.A.
P-Site Similarity: 100 100 100 86.6 N.A. 86.6 40 N.A. N.A. 60 66.6 73.3 N.A. N.A. 60 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 24.3 35.8 N.A.
Protein Similarity: N.A. N.A. N.A. 41.4 52.9 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 33.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 42 9 0 0 0 0 0 0 50 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 17 0 9 0 0 0 0 9 0 9 0 0 0 0 9 % D
% Glu: 17 0 0 50 9 0 0 9 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % F
% Gly: 0 9 0 0 17 0 0 0 9 25 0 0 0 0 0 % G
% His: 0 0 0 17 17 0 9 0 9 0 0 0 0 0 0 % H
% Ile: 0 0 9 0 9 0 0 0 0 0 0 0 0 9 0 % I
% Lys: 9 0 0 0 9 9 17 17 75 9 0 75 0 0 0 % K
% Leu: 0 9 67 0 9 92 0 0 9 0 9 0 67 0 0 % L
% Met: 0 84 0 0 0 0 9 0 0 0 0 0 17 9 9 % M
% Asn: 9 0 0 0 9 0 0 0 0 0 0 9 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % P
% Gln: 0 0 9 17 0 0 0 9 0 0 0 0 0 0 0 % Q
% Arg: 9 0 0 0 25 0 17 0 0 59 92 9 0 0 0 % R
% Ser: 0 0 0 17 0 0 0 42 0 0 0 0 0 0 0 % S
% Thr: 34 0 0 0 0 0 9 0 0 0 0 0 0 0 9 % T
% Val: 0 0 9 0 0 0 0 0 0 0 0 9 0 84 25 % V
% Trp: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _