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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GNMT All Species: 20.91
Human Site: S235 Identified Species: 46
UniProt: Q14749 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14749 NP_061833.1 295 32742 S235 P G A G Q D G S P G L S K F R
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001089876 295 32693 S235 P G A G Q D G S P G L S K F R
Dog Lupus familis XP_532140 295 32695 S235 P G A G Q D G S P G L S K F R
Cat Felis silvestris
Mouse Mus musculus Q9QXF8 293 32657 S233 P G T G R D G S P G F S K F R
Rat Rattus norvegicus P13255 293 32531 A233 P G A G R D G A P G F S K F R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508790 588 65253 S528 P G A G H D G S P G M S K F R
Chicken Gallus gallus XP_001232829 531 58160 S471 P P T E A G A S P E L S K F R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_997981 294 33227 T234 P Q P E G A Q T P P D T S K F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650223 289 32665 N230 M D Y L I A G N K L T S E F R
Honey Bee Apis mellifera XP_625210 292 33740 E233 N E G E E E D E Q K Q I S E F
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784229 290 32784 G231 V V K S D E T G N T N L E K V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 98.6 96.2 N.A. 91.8 91.5 N.A. 39.6 38.9 N.A. 72.5 N.A. 56.9 57.9 N.A. 36.6
Protein Similarity: 100 N.A. 99.6 97.2 N.A. 95.5 95.9 N.A. 45.2 47 N.A. 83.3 N.A. 72.1 72.1 N.A. 53.2
P-Site Identity: 100 N.A. 100 100 N.A. 80 80 N.A. 86.6 53.3 N.A. 13.3 N.A. 26.6 0 N.A. 0
P-Site Similarity: 100 N.A. 100 100 N.A. 86.6 93.3 N.A. 93.3 53.3 N.A. 26.6 N.A. 40 13.3 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 46 0 10 19 10 10 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 10 0 0 10 55 10 0 0 0 10 0 0 0 0 % D
% Glu: 0 10 0 28 10 19 0 10 0 10 0 0 19 10 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 19 0 0 73 19 % F
% Gly: 0 55 10 55 10 10 64 10 0 55 0 0 0 0 0 % G
% His: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 10 0 0 0 0 0 0 10 0 0 0 % I
% Lys: 0 0 10 0 0 0 0 0 10 10 0 0 64 19 0 % K
% Leu: 0 0 0 10 0 0 0 0 0 10 37 10 0 0 0 % L
% Met: 10 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % M
% Asn: 10 0 0 0 0 0 0 10 10 0 10 0 0 0 0 % N
% Pro: 73 10 10 0 0 0 0 0 73 10 0 0 0 0 0 % P
% Gln: 0 10 0 0 28 0 10 0 10 0 10 0 0 0 0 % Q
% Arg: 0 0 0 0 19 0 0 0 0 0 0 0 0 0 73 % R
% Ser: 0 0 0 10 0 0 0 55 0 0 0 73 19 0 0 % S
% Thr: 0 0 19 0 0 0 10 10 0 10 10 10 0 0 0 % T
% Val: 10 10 0 0 0 0 0 0 0 0 0 0 0 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _