KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HLX
All Species:
9.09
Human Site:
S378
Identified Species:
28.57
UniProt:
Q14774
Number Species:
7
Phosphosite Substitution
Charge Score:
-0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14774
NP_068777.1
488
50789
S378
E
G
E
A
E
S
E
S
S
D
S
E
S
L
D
Chimpanzee
Pan troglodytes
XP_525068
493
51402
S383
E
G
E
A
E
S
E
S
S
D
S
E
S
L
D
Rhesus Macaque
Macaca mulatta
XP_001101930
505
52172
S394
E
G
E
A
E
S
E
S
S
D
S
E
S
L
D
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q61670
476
50060
A370
P
S
R
S
E
G
E
A
E
S
E
S
S
D
S
Rat
Rattus norvegicus
A0JPN1
476
50008
A370
P
S
R
S
E
G
E
A
E
S
E
S
S
D
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q9I9H2
331
36665
R225
K
I
W
F
Q
N
R
R
M
K
W
R
N
S
K
Zebra Danio
Brachydanio rerio
Q9PTU1
314
34662
L208
S
K
P
D
R
K
K
L
A
A
K
L
G
L
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001121170
229
25911
R123
N
Q
S
E
S
N
T
R
R
K
R
S
W
S
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
89.9
N.A.
N.A.
86.8
87.5
N.A.
N.A.
N.A.
25
24.5
N.A.
N.A.
24.1
N.A.
N.A.
Protein Similarity:
100
98.7
93
N.A.
N.A.
90.3
90.9
N.A.
N.A.
N.A.
37.2
37
N.A.
N.A.
32.7
N.A.
N.A.
P-Site Identity:
100
100
100
N.A.
N.A.
20
20
N.A.
N.A.
N.A.
0
6.6
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
100
100
100
N.A.
N.A.
33.3
33.3
N.A.
N.A.
N.A.
26.6
20
N.A.
N.A.
6.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
38
0
0
0
25
13
13
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
13
0
0
0
0
0
38
0
0
0
25
38
% D
% Glu:
38
0
38
13
63
0
63
0
25
0
25
38
0
0
0
% E
% Phe:
0
0
0
13
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
38
0
0
0
25
0
0
0
0
0
0
13
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
13
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
13
13
0
0
0
13
13
0
0
25
13
0
0
0
25
% K
% Leu:
0
0
0
0
0
0
0
13
0
0
0
13
0
50
0
% L
% Met:
0
0
0
0
0
0
0
0
13
0
0
0
0
0
0
% M
% Asn:
13
0
0
0
0
25
0
0
0
0
0
0
13
0
0
% N
% Pro:
25
0
13
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
13
0
0
13
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
25
0
13
0
13
25
13
0
13
13
0
0
13
% R
% Ser:
13
25
13
25
13
38
0
38
38
25
38
38
63
25
25
% S
% Thr:
0
0
0
0
0
0
13
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
13
0
0
0
0
0
0
0
13
0
13
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _