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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CASP8
All Species:
10.91
Human Site:
S219
Identified Species:
24
UniProt:
Q14790
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14790
NP_001073593.1
479
55391
S219
P
R
E
Q
D
S
E
S
Q
T
L
D
K
V
Y
Chimpanzee
Pan troglodytes
Q5IS54
277
31588
D28
I
H
G
S
Q
S
M
D
S
G
I
S
L
D
N
Rhesus Macaque
Macaca mulatta
XP_001091080
569
65150
S309
P
R
E
Q
D
S
E
S
Q
T
L
D
K
V
Y
Dog
Lupus familis
XP_545593
484
55003
L219
L
H
Q
K
E
E
E
L
F
S
P
S
D
I
N
Cat
Felis silvestris
Mouse
Mus musculus
O89110
480
55338
S221
P
R
E
Q
D
S
E
S
R
T
S
D
K
V
Y
Rat
Rattus norvegicus
P55213
277
31473
D28
I
H
G
S
K
S
M
D
S
G
I
Y
L
D
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513568
471
53077
P206
Q
G
D
Q
G
S
Q
P
Q
Q
N
G
D
F
Y
Chicken
Gallus gallus
Q98943
424
47941
I175
E
P
R
G
L
A
L
I
L
S
N
I
H
F
S
Frog
Xenopus laevis
P55866
282
32106
L33
R
S
L
Q
N
C
D
L
K
D
I
E
R
K
T
Zebra Danio
Brachydanio rerio
NP_571585
476
54945
S200
V
F
L
N
N
P
V
S
E
T
M
E
R
E
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P42573
503
56598
A204
R
N
R
S
F
S
K
A
S
G
P
T
Q
Y
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
26.1
79.4
38.6
N.A.
67.2
25.8
N.A.
56.5
24.2
23.1
42.5
N.A.
N.A.
N.A.
21.4
N.A.
Protein Similarity:
100
38
82
58
N.A.
79.5
38.4
N.A.
72.2
45.7
35.9
59.5
N.A.
N.A.
N.A.
40.1
N.A.
P-Site Identity:
100
6.6
100
6.6
N.A.
86.6
6.6
N.A.
26.6
0
6.6
13.3
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
100
13.3
100
40
N.A.
93.3
13.3
N.A.
40
13.3
46.6
46.6
N.A.
N.A.
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
10
0
10
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
10
0
28
0
10
19
0
10
0
28
19
19
0
% D
% Glu:
10
0
28
0
10
10
37
0
10
0
0
19
0
10
0
% E
% Phe:
0
10
0
0
10
0
0
0
10
0
0
0
0
19
0
% F
% Gly:
0
10
19
10
10
0
0
0
0
28
0
10
0
0
0
% G
% His:
0
28
0
0
0
0
0
0
0
0
0
0
10
0
0
% H
% Ile:
19
0
0
0
0
0
0
10
0
0
28
10
0
10
10
% I
% Lys:
0
0
0
10
10
0
10
0
10
0
0
0
28
10
0
% K
% Leu:
10
0
19
0
10
0
10
19
10
0
19
0
19
0
0
% L
% Met:
0
0
0
0
0
0
19
0
0
0
10
0
0
0
0
% M
% Asn:
0
10
0
10
19
0
0
0
0
0
19
0
0
0
19
% N
% Pro:
28
10
0
0
0
10
0
10
0
0
19
0
0
0
0
% P
% Gln:
10
0
10
46
10
0
10
0
28
10
0
0
10
0
0
% Q
% Arg:
19
28
19
0
0
0
0
0
10
0
0
0
19
0
10
% R
% Ser:
0
10
0
28
0
64
0
37
28
19
10
19
0
0
19
% S
% Thr:
0
0
0
0
0
0
0
0
0
37
0
10
0
0
10
% T
% Val:
10
0
0
0
0
0
10
0
0
0
0
0
0
28
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
10
0
10
37
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _