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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GPNMB
All Species:
19.7
Human Site:
Y519
Identified Species:
48.15
UniProt:
Q14956
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14956
NP_001005340.1
572
63923
Y519
T
V
I
S
L
L
V
Y
K
K
H
K
E
Y
N
Chimpanzee
Pan troglodytes
XP_001157101
572
63901
Y519
T
V
I
S
L
L
V
Y
K
K
H
K
E
Y
N
Rhesus Macaque
Macaca mulatta
XP_001099643
573
63509
Y520
T
V
I
S
L
L
V
Y
K
K
H
K
K
Y
K
Dog
Lupus familis
XP_539472
554
61712
I512
K
H
K
E
Y
N
L
I
E
N
S
T
G
I
V
Cat
Felis silvestris
Mouse
Mus musculus
Q99P91
574
63656
Y523
T
M
V
T
I
L
L
Y
K
K
H
K
A
Y
K
Rat
Rattus norvegicus
Q6P7C7
572
63713
Y521
T
M
V
T
I
L
L
Y
K
K
H
K
T
Y
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512572
571
63478
H520
I
V
I
T
L
F
L
H
R
R
Y
K
E
Y
K
Chicken
Gallus gallus
Q98917
763
77019
R711
G
T
A
A
Y
T
Y
R
R
V
K
Y
S
P
L
Frog
Xenopus laevis
NP_001089087
597
65508
K550
V
G
A
I
L
L
K
K
Y
K
E
Y
R
P
I
Zebra Danio
Brachydanio rerio
XP_691804
621
69406
Y572
A
F
I
A
Y
M
V
Y
K
R
Y
K
V
Y
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
95.6
75.6
N.A.
70
68.7
N.A.
61.3
25.1
48.7
33.4
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
96.5
84
N.A.
82.9
82.6
N.A.
73.5
40.2
63.9
52.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
86.6
0
N.A.
53.3
53.3
N.A.
40
0
20
40
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
13.3
N.A.
86.6
86.6
N.A.
80
13.3
20
66.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
20
20
0
0
0
0
0
0
0
0
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
10
0
0
0
0
10
0
10
0
30
0
0
% E
% Phe:
0
10
0
0
0
10
0
0
0
0
0
0
0
0
0
% F
% Gly:
10
10
0
0
0
0
0
0
0
0
0
0
10
0
0
% G
% His:
0
10
0
0
0
0
0
10
0
0
50
0
0
0
0
% H
% Ile:
10
0
50
10
20
0
0
10
0
0
0
0
0
10
10
% I
% Lys:
10
0
10
0
0
0
10
10
60
60
10
70
10
0
40
% K
% Leu:
0
0
0
0
50
60
40
0
0
0
0
0
0
0
10
% L
% Met:
0
20
0
0
0
10
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
10
0
0
0
10
0
0
0
0
20
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
20
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
10
20
20
0
0
10
0
10
% R
% Ser:
0
0
0
30
0
0
0
0
0
0
10
0
10
0
0
% S
% Thr:
50
10
0
30
0
10
0
0
0
0
0
10
10
0
0
% T
% Val:
10
40
20
0
0
0
40
0
0
10
0
0
10
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
30
0
10
60
10
0
20
20
0
70
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _