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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CUL7
All Species:
18.79
Human Site:
T546
Identified Species:
59.05
UniProt:
Q14999
Number Species:
7
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14999
NP_055595.2
1698
191161
T546
L
A
Q
D
L
L
L
T
L
P
Q
R
L
N
D
Chimpanzee
Pan troglodytes
XP_001136655
1698
191188
T546
L
A
Q
D
L
L
L
T
L
P
Q
R
L
N
D
Rhesus Macaque
Macaca mulatta
XP_001088003
1810
203195
T659
L
A
Q
D
L
L
L
T
L
P
Q
R
L
N
D
Dog
Lupus familis
XP_538928
1683
189926
A546
L
A
Q
D
L
L
L
A
L
P
Q
R
L
D
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8VE73
1689
192274
S536
L
A
Q
D
L
L
L
S
L
P
Q
Q
L
E
D
Rat
Rattus norvegicus
XP_001056520
1696
193015
S534
L
A
Q
D
L
M
L
S
L
P
Q
Q
L
D
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508500
1587
174471
R555
L
A
Q
R
L
V
L
R
L
S
R
Q
C
Q
G
Chicken
Gallus gallus
XP_419326
1368
150521
S396
L
E
D
Y
E
Q
V
S
A
G
D
E
G
E
F
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
91
88.2
N.A.
78
80.5
N.A.
48.2
41.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.8
92.3
92.5
N.A.
87.2
88.8
N.A.
62.1
53.8
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
86.6
N.A.
80
73.3
N.A.
40
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
100
N.A.
60
20
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
88
0
0
0
0
0
13
13
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
13
0
0
% C
% Asp:
0
0
13
75
0
0
0
0
0
0
13
0
0
25
75
% D
% Glu:
0
13
0
0
13
0
0
0
0
0
0
13
0
25
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
13
% F
% Gly:
0
0
0
0
0
0
0
0
0
13
0
0
13
0
13
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
100
0
0
0
88
63
88
0
88
0
0
0
75
0
0
% L
% Met:
0
0
0
0
0
13
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
38
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
75
0
0
0
0
0
% P
% Gln:
0
0
88
0
0
13
0
0
0
0
75
38
0
13
0
% Q
% Arg:
0
0
0
13
0
0
0
13
0
0
13
50
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
38
0
13
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
38
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
13
13
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
13
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _