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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SHPRH All Species: 28.48
Human Site: T1089 Identified Species: 62.67
UniProt: Q149N8 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q149N8 NP_001036148.1 1683 193079 T1089 R H P G I P P T L R D G R L E
Chimpanzee Pan troglodytes XP_001172976 1683 193077 T1089 R H P G I P P T L R D G R L E
Rhesus Macaque Macaca mulatta XP_001086512 1683 193033 T1089 K H P G I P P T L R D G R L E
Dog Lupus familis XP_533438 1685 193077 T1091 K H P G I P P T L R D G R L E
Cat Felis silvestris
Mouse Mus musculus Q7TPQ3 1674 191472 T1080 K H P G I P P T L R D G R L E
Rat Rattus norvegicus NP_001100940 1701 194686 T1107 K H P G I P P T L R D G R L E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506895 1042 119725 N523 E L V L R V Q N E L T S N Y K
Chicken Gallus gallus XP_419651 1681 192161 T1087 K H T G I P P T L R D S Q L S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648034 1270 148040 S752 L E K R F E G S T L D L L A T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002329202 1320 149464 P802 L R S L Q Q S P M T M E E I L
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_181609 1664 188054 T1042 R E S S R F R T I H G M K L H
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 98 92.5 N.A. 86 84.6 N.A. 52.7 72 N.A. N.A. N.A. 25.6 N.A. N.A. N.A.
Protein Similarity: 100 99.6 98.9 95.7 N.A. 91.8 90.7 N.A. 56.9 82.2 N.A. N.A. N.A. 42.3 N.A. N.A. N.A.
P-Site Identity: 100 100 93.3 93.3 N.A. 93.3 93.3 N.A. 0 66.6 N.A. N.A. N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 6.6 80 N.A. N.A. N.A. 13.3 N.A. N.A. N.A.
Percent
Protein Identity: 20.9 N.A. N.A. 20.8 N.A. N.A.
Protein Similarity: 37.7 N.A. N.A. 38.6 N.A. N.A.
P-Site Identity: 0 N.A. N.A. 20 N.A. N.A.
P-Site Similarity: 13.3 N.A. N.A. 33.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 73 0 0 0 0 % D
% Glu: 10 19 0 0 0 10 0 0 10 0 0 10 10 0 55 % E
% Phe: 0 0 0 0 10 10 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 64 0 0 10 0 0 0 10 55 0 0 0 % G
% His: 0 64 0 0 0 0 0 0 0 10 0 0 0 0 10 % H
% Ile: 0 0 0 0 64 0 0 0 10 0 0 0 0 10 0 % I
% Lys: 46 0 10 0 0 0 0 0 0 0 0 0 10 0 10 % K
% Leu: 19 10 0 19 0 0 0 0 64 19 0 10 10 73 10 % L
% Met: 0 0 0 0 0 0 0 0 10 0 10 10 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 10 0 0 0 0 10 0 0 % N
% Pro: 0 0 55 0 0 64 64 10 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 10 10 10 0 0 0 0 0 10 0 0 % Q
% Arg: 28 10 0 10 19 0 10 0 0 64 0 0 55 0 0 % R
% Ser: 0 0 19 10 0 0 10 10 0 0 0 19 0 0 10 % S
% Thr: 0 0 10 0 0 0 0 73 10 10 10 0 0 0 10 % T
% Val: 0 0 10 0 0 10 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _