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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NCAPH All Species: 0.61
Human Site: T518 Identified Species: 1.11
UniProt: Q15003 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15003 NP_056156.2 741 82563 T518 D F N Y N V D T L V Q L H L K
Chimpanzee Pan troglodytes XP_001148661 741 82518 A518 D F N Y D V D A L V Q L H L K
Rhesus Macaque Macaca mulatta XP_001097565 209 22886 E10 Q G R R A E T E H Y E E I E D
Dog Lupus familis XP_532948 916 102619 H554 D F L Y E T D H L V Q L Y L K
Cat Felis silvestris
Mouse Mus musculus Q8C156 731 82284 N511 D F H Y E T D N L I Q L H L K
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513175 869 95987 N648 N F H Y E P D N I I Q L N L K
Chicken Gallus gallus XP_001231605 383 41693 E183 V G S P E E E E D S T A S S S
Frog Xenopus laevis O13067 699 77759 N500 D F H Y D P D N I A R M S L R
Zebra Danio Brachydanio rerio NP_001073665 690 76324 S490 A D F Q Y P P S N L S Q L N L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001187579 678 74012 M479 M F L R P N F M M K R Q A A N
Poplar Tree Populus trichocarpa XP_002321137 605 68469 L406 D I D F T K A L D E E M P D V
Maize Zea mays NP_001144998 674 75246 K475 F A A P K N P K T L L F P A N
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_180818 671 75347 L472 K N P K T L L L P A S R T P C
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 27.1 67.4 N.A. 77.8 N.A. N.A. 58 29 54.7 46.9 N.A. N.A. N.A. N.A. 35
Protein Similarity: 100 99.4 27.9 71.8 N.A. 83.8 N.A. N.A. 67 38.5 69.2 61.4 N.A. N.A. N.A. N.A. 50.6
P-Site Identity: 100 86.6 0 66.6 N.A. 66.6 N.A. N.A. 46.6 0 33.3 0 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 93.3 6.6 73.3 N.A. 80 N.A. N.A. 80 13.3 73.3 13.3 N.A. N.A. N.A. N.A. 20
Percent
Protein Identity: 25.6 25.2 N.A. 23.7 N.A. N.A.
Protein Similarity: 43 41.8 N.A. 42.2 N.A. N.A.
P-Site Identity: 6.6 0 N.A. 0 N.A. N.A.
P-Site Similarity: 33.3 6.6 N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 8 0 8 0 8 8 0 16 0 8 8 16 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % C
% Asp: 47 8 8 0 16 0 47 0 16 0 0 0 0 8 8 % D
% Glu: 0 0 0 0 31 16 8 16 0 8 16 8 0 8 0 % E
% Phe: 8 54 8 8 0 0 8 0 0 0 0 8 0 0 0 % F
% Gly: 0 16 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 24 0 0 0 0 8 8 0 0 0 24 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 16 16 0 0 8 0 0 % I
% Lys: 8 0 0 8 8 8 0 8 0 8 0 0 0 0 39 % K
% Leu: 0 0 16 0 0 8 8 16 31 16 8 39 8 47 8 % L
% Met: 8 0 0 0 0 0 0 8 8 0 0 16 0 0 0 % M
% Asn: 8 8 16 0 8 16 0 24 8 0 0 0 8 8 16 % N
% Pro: 0 0 8 16 8 24 16 0 8 0 0 0 16 8 0 % P
% Gln: 8 0 0 8 0 0 0 0 0 0 39 16 0 0 0 % Q
% Arg: 0 0 8 16 0 0 0 0 0 0 16 8 0 0 8 % R
% Ser: 0 0 8 0 0 0 0 8 0 8 16 0 16 8 8 % S
% Thr: 0 0 0 0 16 16 8 8 8 0 8 0 8 0 0 % T
% Val: 8 0 0 0 0 16 0 0 0 24 0 0 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 47 8 0 0 0 0 8 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _