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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MLC1
All Species:
12.12
Human Site:
T17
Identified Species:
33.33
UniProt:
Q15049
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15049
NP_055981.1
377
41141
T17
L
A
Y
D
R
M
P
T
L
E
R
G
R
Q
D
Chimpanzee
Pan troglodytes
XP_515212
315
34494
Rhesus Macaque
Macaca mulatta
XP_001111585
377
41140
T17
L
A
Y
D
R
M
P
T
L
E
R
G
R
Q
D
Dog
Lupus familis
XP_848790
515
56009
T160
L
G
Y
D
R
M
P
T
L
E
R
G
R
P
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8VHK5
382
41577
R23
M
P
T
L
E
R
G
R
Q
D
A
G
R
Q
D
Rat
Rattus norvegicus
NP_001101575
406
44287
R47
M
P
T
L
E
R
G
R
Q
D
A
G
R
Q
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506189
379
42549
T18
F
S
Y
D
R
M
S
T
L
E
C
G
R
Q
D
Chicken
Gallus gallus
XP_415981
387
42441
K26
S
F
P
A
R
I
L
K
S
Y
S
V
I
E
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001098409
391
42423
E34
G
T
L
S
R
H
L
E
R
E
R
L
E
R
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.2
96.8
62.5
N.A.
87.9
82.5
N.A.
74.9
63.8
N.A.
52.6
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
80.1
98.1
66.2
N.A.
92.9
86.6
N.A.
87.3
77
N.A.
71.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
0
100
86.6
N.A.
26.6
26.6
N.A.
73.3
6.6
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
0
100
86.6
N.A.
40
40
N.A.
80
20
N.A.
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
23
0
12
0
0
0
0
0
0
23
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% C
% Asp:
0
0
0
45
0
0
0
0
0
23
0
0
0
0
78
% D
% Glu:
0
0
0
0
23
0
0
12
0
56
0
0
12
12
0
% E
% Phe:
12
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
12
12
0
0
0
0
23
0
0
0
0
67
0
0
0
% G
% His:
0
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
12
0
0
0
0
0
0
12
0
0
% I
% Lys:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% K
% Leu:
34
0
12
23
0
0
23
0
45
0
0
12
0
0
0
% L
% Met:
23
0
0
0
0
45
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
23
12
0
0
0
34
0
0
0
0
0
0
12
0
% P
% Gln:
0
0
0
0
0
0
0
0
23
0
0
0
0
56
0
% Q
% Arg:
0
0
0
0
67
23
0
23
12
0
45
0
67
12
0
% R
% Ser:
12
12
0
12
0
0
12
0
12
0
12
0
0
0
0
% S
% Thr:
0
12
23
0
0
0
0
45
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
12
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
45
0
0
0
0
0
0
12
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _