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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ARHGEF6
All Species:
27.58
Human Site:
S180
Identified Species:
60.67
UniProt:
Q15052
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15052
NP_004831.1
776
87499
S180
Q
T
N
E
D
E
L
S
V
C
K
G
D
I
I
Chimpanzee
Pan troglodytes
XP_509742
901
100045
V287
L
S
F
S
K
G
D
V
I
H
V
T
R
V
E
Rhesus Macaque
Macaca mulatta
XP_001083544
776
87430
S180
Q
T
N
E
D
E
L
S
V
C
K
G
D
I
I
Dog
Lupus familis
XP_852793
775
87356
S179
Q
T
N
E
D
E
L
S
V
C
K
G
D
I
I
Cat
Felis silvestris
Mouse
Mus musculus
Q8K4I3
771
87033
S179
Q
T
N
E
D
E
L
S
V
C
K
G
D
I
I
Rat
Rattus norvegicus
Q5XXR3
772
86995
S180
Q
T
N
E
D
E
L
S
V
C
K
G
D
I
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514136
771
86999
S178
Q
T
N
E
D
E
L
S
V
S
K
G
D
I
I
Chicken
Gallus gallus
Q5ZLR6
764
85889
Y180
V
N
K
G
D
I
I
Y
V
T
R
V
E
E
G
Frog
Xenopus laevis
NP_001085995
425
47918
Zebra Danio
Brachydanio rerio
XP_686581
795
89103
S178
Q
N
N
E
D
E
L
S
F
S
K
G
E
L
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784106
581
64090
K29
R
H
N
F
E
G
S
K
D
D
E
L
N
F
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
52.1
98.5
93.8
N.A.
91.1
91.2
N.A.
80.8
74.4
33.6
60.7
N.A.
N.A.
N.A.
N.A.
28
Protein Similarity:
100
67.5
99.3
97.6
N.A.
95.8
96
N.A.
89.5
86.5
43.5
78.1
N.A.
N.A.
N.A.
N.A.
42.9
P-Site Identity:
100
0
100
100
N.A.
100
100
N.A.
93.3
13.3
0
66.6
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
20
100
100
N.A.
100
100
N.A.
93.3
33.3
0
80
N.A.
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
46
0
0
0
0
0
% C
% Asp:
0
0
0
0
73
0
10
0
10
10
0
0
55
0
0
% D
% Glu:
0
0
0
64
10
64
0
0
0
0
10
0
19
10
10
% E
% Phe:
0
0
10
10
0
0
0
0
10
0
0
0
0
10
0
% F
% Gly:
0
0
0
10
0
19
0
0
0
0
0
64
0
0
10
% G
% His:
0
10
0
0
0
0
0
0
0
10
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
10
10
0
10
0
0
0
0
55
64
% I
% Lys:
0
0
10
0
10
0
0
10
0
0
64
0
0
0
0
% K
% Leu:
10
0
0
0
0
0
64
0
0
0
0
10
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
19
73
0
0
0
0
0
0
0
0
0
10
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
64
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% Q
% Arg:
10
0
0
0
0
0
0
0
0
0
10
0
10
0
0
% R
% Ser:
0
10
0
10
0
0
10
64
0
19
0
0
0
0
0
% S
% Thr:
0
55
0
0
0
0
0
0
0
10
0
10
0
0
0
% T
% Val:
10
0
0
0
0
0
0
10
64
0
10
10
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _