KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ARHGEF6
All Species:
21.21
Human Site:
S561
Identified Species:
46.67
UniProt:
Q15052
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15052
NP_004831.1
776
87499
S561
S
S
L
S
K
T
S
S
S
S
C
S
A
H
S
Chimpanzee
Pan troglodytes
XP_509742
901
100045
P692
H
A
D
S
K
P
A
P
L
T
P
A
Y
H
T
Rhesus Macaque
Macaca mulatta
XP_001083544
776
87430
S561
S
S
L
S
K
T
S
S
S
S
C
S
A
H
S
Dog
Lupus familis
XP_852793
775
87356
S560
S
S
L
S
K
T
S
S
S
S
C
S
A
H
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8K4I3
771
87033
S560
G
S
L
S
K
T
S
S
S
S
C
S
T
H
S
Rat
Rattus norvegicus
Q5XXR3
772
86995
S561
S
S
L
S
K
T
S
S
S
S
C
S
T
H
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514136
771
86999
A557
P
G
P
T
L
T
K
A
Q
S
W
S
A
H
S
Chicken
Gallus gallus
Q5ZLR6
764
85889
T549
T
C
N
T
V
S
K
T
Q
S
W
S
A
H
S
Frog
Xenopus laevis
NP_001085995
425
47918
S227
K
S
S
E
K
P
V
S
P
K
S
T
T
L
K
Zebra Danio
Brachydanio rerio
XP_686581
795
89103
K573
T
S
I
Q
L
N
S
K
S
N
V
M
F
L
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784106
581
64090
K383
A
Q
G
L
E
K
T
K
I
I
C
P
A
V
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
52.1
98.5
93.8
N.A.
91.1
91.2
N.A.
80.8
74.4
33.6
60.7
N.A.
N.A.
N.A.
N.A.
28
Protein Similarity:
100
67.5
99.3
97.6
N.A.
95.8
96
N.A.
89.5
86.5
43.5
78.1
N.A.
N.A.
N.A.
N.A.
42.9
P-Site Identity:
100
20
100
100
N.A.
86.6
93.3
N.A.
40
33.3
20
20
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
53.3
100
100
N.A.
86.6
93.3
N.A.
53.3
60
26.6
40
N.A.
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
0
0
0
0
10
10
0
0
0
10
55
0
0
% A
% Cys:
0
10
0
0
0
0
0
0
0
0
55
0
0
0
10
% C
% Asp:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
10
10
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% F
% Gly:
10
10
10
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
10
0
0
0
0
0
0
0
0
0
0
0
0
73
0
% H
% Ile:
0
0
10
0
0
0
0
0
10
10
0
0
0
0
0
% I
% Lys:
10
0
0
0
64
10
19
19
0
10
0
0
0
0
10
% K
% Leu:
0
0
46
10
19
0
0
0
10
0
0
0
0
19
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
0
0
10
0
0
10
0
0
0
10
0
0
0
0
0
% N
% Pro:
10
0
10
0
0
19
0
10
10
0
10
10
0
0
0
% P
% Gln:
0
10
0
10
0
0
0
0
19
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
37
64
10
55
0
10
55
55
55
64
10
64
0
0
64
% S
% Thr:
19
0
0
19
0
55
10
10
0
10
0
10
28
0
10
% T
% Val:
0
0
0
0
10
0
10
0
0
0
10
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
19
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _