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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ARHGEF6
All Species:
15.76
Human Site:
S678
Identified Species:
34.67
UniProt:
Q15052
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15052
NP_004831.1
776
87499
S678
N
F
Q
Q
G
H
G
S
S
T
R
K
D
S
I
Chimpanzee
Pan troglodytes
XP_509742
901
100045
S809
K
T
R
Q
T
L
N
S
S
S
R
K
E
S
A
Rhesus Macaque
Macaca mulatta
XP_001083544
776
87430
S678
N
F
Q
Q
G
H
G
S
S
T
R
K
D
S
I
Dog
Lupus familis
XP_852793
775
87356
S677
N
F
Q
Q
G
H
G
S
S
A
R
K
D
S
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8K4I3
771
87033
K677
S
F
Q
Q
G
T
R
K
D
S
V
P
Q
V
L
Rat
Rattus norvegicus
Q5XXR3
772
86995
K678
S
F
Q
Q
G
T
R
K
D
S
V
P
Q
V
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514136
771
86999
S675
G
F
Q
Q
T
S
S
S
R
K
D
S
I
P
Q
Chicken
Gallus gallus
Q5ZLR6
764
85889
S666
G
F
Q
Q
A
L
S
S
G
S
R
K
D
S
I
Frog
Xenopus laevis
NP_001085995
425
47918
A341
Q
I
K
S
L
Y
L
A
Y
C
A
N
H
P
S
Zebra Danio
Brachydanio rerio
XP_686581
795
89103
A704
S
L
H
Q
S
T
T
A
V
R
K
E
C
V
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784106
581
64090
P497
K
E
G
S
G
K
S
P
R
G
K
R
R
N
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
52.1
98.5
93.8
N.A.
91.1
91.2
N.A.
80.8
74.4
33.6
60.7
N.A.
N.A.
N.A.
N.A.
28
Protein Similarity:
100
67.5
99.3
97.6
N.A.
95.8
96
N.A.
89.5
86.5
43.5
78.1
N.A.
N.A.
N.A.
N.A.
42.9
P-Site Identity:
100
40
100
86.6
N.A.
26.6
26.6
N.A.
26.6
60
0
6.6
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
60
100
93.3
N.A.
46.6
46.6
N.A.
26.6
66.6
20
33.3
N.A.
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
0
0
19
0
10
10
0
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
10
0
0
10
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
19
0
10
0
37
0
0
% D
% Glu:
0
10
0
0
0
0
0
0
0
0
0
10
10
0
0
% E
% Phe:
0
64
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
19
0
10
0
55
0
28
0
10
10
0
0
0
0
0
% G
% His:
0
0
10
0
0
28
0
0
0
0
0
0
10
0
0
% H
% Ile:
0
10
0
0
0
0
0
0
0
0
0
0
10
0
28
% I
% Lys:
19
0
10
0
0
10
0
19
0
10
19
46
0
0
0
% K
% Leu:
0
10
0
0
10
19
10
0
0
0
0
0
0
0
37
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
28
0
0
0
0
0
10
0
0
0
0
10
0
10
0
% N
% Pro:
0
0
0
0
0
0
0
10
0
0
0
19
0
19
10
% P
% Gln:
10
0
64
82
0
0
0
0
0
0
0
0
19
0
10
% Q
% Arg:
0
0
10
0
0
0
19
0
19
10
46
10
10
0
0
% R
% Ser:
28
0
0
19
10
10
28
55
37
37
0
10
0
46
10
% S
% Thr:
0
10
0
0
19
28
10
0
0
19
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
10
0
19
0
0
28
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
10
0
0
10
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _