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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ARHGEF6
All Species:
29.7
Human Site:
S703
Identified Species:
65.33
UniProt:
Q15052
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15052
NP_004831.1
776
87499
S703
L
I
I
E
E
T
R
S
N
G
Q
T
I
M
E
Chimpanzee
Pan troglodytes
XP_509742
901
100045
S834
I
I
V
E
E
T
K
S
N
G
Q
T
V
I
E
Rhesus Macaque
Macaca mulatta
XP_001083544
776
87430
S703
L
I
I
E
E
T
R
S
N
G
Q
T
I
M
E
Dog
Lupus familis
XP_852793
775
87356
S702
L
I
I
E
E
T
R
S
N
G
Q
T
I
I
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8K4I3
771
87033
S708
Q
T
I
I
E
E
K
S
L
V
D
T
V
Y
A
Rat
Rattus norvegicus
Q5XXR3
772
86995
S709
Q
T
I
I
E
E
K
S
L
V
D
T
V
Y
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514136
771
86999
S698
I
I
V
E
E
T
R
S
N
G
Q
T
V
T
E
Chicken
Gallus gallus
Q5ZLR6
764
85889
S691
I
I
I
E
E
T
R
S
N
G
Q
T
V
T
E
Frog
Xenopus laevis
NP_001085995
425
47918
M364
S
E
E
L
G
E
F
M
E
M
K
G
A
N
S
Zebra Danio
Brachydanio rerio
XP_686581
795
89103
S728
I
I
V
E
D
I
K
S
N
G
Q
T
T
I
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784106
581
64090
A520
G
D
K
N
V
E
A
A
I
I
Q
K
L
D
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
52.1
98.5
93.8
N.A.
91.1
91.2
N.A.
80.8
74.4
33.6
60.7
N.A.
N.A.
N.A.
N.A.
28
Protein Similarity:
100
67.5
99.3
97.6
N.A.
95.8
96
N.A.
89.5
86.5
43.5
78.1
N.A.
N.A.
N.A.
N.A.
42.9
P-Site Identity:
100
66.6
100
93.3
N.A.
26.6
26.6
N.A.
73.3
80
0
53.3
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
40
40
N.A.
93.3
93.3
6.6
86.6
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
10
10
0
0
0
0
10
0
19
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
10
0
0
0
0
0
19
0
0
10
0
% D
% Glu:
0
10
10
64
73
37
0
0
10
0
0
0
0
0
64
% E
% Phe:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% F
% Gly:
10
0
0
0
10
0
0
0
0
64
0
10
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
37
64
55
19
0
10
0
0
10
10
0
0
28
28
0
% I
% Lys:
0
0
10
0
0
0
37
0
0
0
10
10
0
0
0
% K
% Leu:
28
0
0
10
0
0
0
0
19
0
0
0
10
0
0
% L
% Met:
0
0
0
0
0
0
0
10
0
10
0
0
0
19
0
% M
% Asn:
0
0
0
10
0
0
0
0
64
0
0
0
0
10
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
19
0
0
0
0
0
0
0
0
0
73
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
46
0
0
0
0
0
0
0
0
% R
% Ser:
10
0
0
0
0
0
0
82
0
0
0
0
0
0
19
% S
% Thr:
0
19
0
0
0
55
0
0
0
0
0
82
10
19
0
% T
% Val:
0
0
28
0
10
0
0
0
0
19
0
0
46
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
19
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _