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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ARHGEF6 All Species: 24.85
Human Site: T760 Identified Species: 54.67
UniProt: Q15052 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15052 NP_004831.1 776 87499 T760 V R R L L K Q T D E C I R G E
Chimpanzee Pan troglodytes XP_509742 901 100045 V884 R K D L E K L V R K V L K N M
Rhesus Macaque Macaca mulatta XP_001083544 776 87430 T760 V R R L L K Q T D E C I R A E
Dog Lupus familis XP_852793 775 87356 T759 V R R L L K Q T D E C I R A E
Cat Felis silvestris
Mouse Mus musculus Q8K4I3 771 87033 T755 V R K L L K Q T D E C I R S E
Rat Rattus norvegicus Q5XXR3 772 86995 T756 V R K L L K Q T D E S I R A E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514136 771 86999 T755 V R R L L K Q T D E C V R D E
Chicken Gallus gallus Q5ZLR6 764 85889 T748 V R R L L K Q T D E C S R E E
Frog Xenopus laevis NP_001085995 425 47918 P410 E D Y H P D R P D I Q K S M T
Zebra Danio Brachydanio rerio XP_686581 795 89103 L774 E Q K S R K E L E R V V R K L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784106 581 64090 G566 D R K Q N L N G Y S A S P V G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 52.1 98.5 93.8 N.A. 91.1 91.2 N.A. 80.8 74.4 33.6 60.7 N.A. N.A. N.A. N.A. 28
Protein Similarity: 100 67.5 99.3 97.6 N.A. 95.8 96 N.A. 89.5 86.5 43.5 78.1 N.A. N.A. N.A. N.A. 42.9
P-Site Identity: 100 13.3 93.3 93.3 N.A. 86.6 80 N.A. 86.6 86.6 6.6 13.3 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 40 93.3 93.3 N.A. 93.3 86.6 N.A. 93.3 86.6 13.3 46.6 N.A. N.A. N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 10 0 0 28 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 55 0 0 0 0 % C
% Asp: 10 10 10 0 0 10 0 0 73 0 0 0 0 10 0 % D
% Glu: 19 0 0 0 10 0 10 0 10 64 0 0 0 10 64 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 10 0 0 0 0 0 10 10 % G
% His: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 10 0 46 0 0 0 % I
% Lys: 0 10 37 0 0 82 0 0 0 10 0 10 10 10 0 % K
% Leu: 0 0 0 73 64 10 10 10 0 0 0 10 0 0 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 10 % M
% Asn: 0 0 0 0 10 0 10 0 0 0 0 0 0 10 0 % N
% Pro: 0 0 0 0 10 0 0 10 0 0 0 0 10 0 0 % P
% Gln: 0 10 0 10 0 0 64 0 0 0 10 0 0 0 0 % Q
% Arg: 10 73 46 0 10 0 10 0 10 10 0 0 73 0 0 % R
% Ser: 0 0 0 10 0 0 0 0 0 10 10 19 10 10 0 % S
% Thr: 0 0 0 0 0 0 0 64 0 0 0 0 0 0 10 % T
% Val: 64 0 0 0 0 0 0 10 0 0 19 19 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 0 0 0 0 10 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _