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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDIA6 All Species: 18.18
Human Site: S169 Identified Species: 25
UniProt: Q15084 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15084 NP_005733.1 440 48121 S169 V I E L T D D S F D K N V L D
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001095159 524 57323 S253 V I E L T D D S F D E N V L D
Dog Lupus familis XP_532876 440 48280 S169 V I E L T D D S F D K N V L D
Cat Felis silvestris
Mouse Mus musculus Q922R8 440 48082 T169 V V E L T D D T F D K N V L D
Rat Rattus norvegicus Q63081 440 48155 T169 V V E L T D D T F D K N V L D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505713 415 44653 C165 V E F Y A P W C G H C K N L E
Chicken Gallus gallus Q8JG64 505 56163 F169 S G D A Y S E F M K A A N N L
Frog Xenopus laevis NP_001086643 442 47765 D169 K D V I E L T D D T F D K N V
Zebra Danio Brachydanio rerio NP_922915 440 48022 N169 V V E L T D D N F D R T V L E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P54399 496 55763 F209 G V V L F K P F D D K K S V F
Honey Bee Apis mellifera XP_395981 427 47177 N165 T F D N I V M N S D D M W L I
Nematode Worm Caenorhab. elegans Q11067 440 47710 E168 G S G N E V V E L T D A N F E
Sea Urchin Strong. purpuratus XP_790496 399 42463 G157 S G G S G S G G S G G K A D D
Poplar Tree Populus trichocarpa XP_002320494 404 43880 A162 L W I V E F F A P W C G H C K
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O22263 361 39478 A119 K Y E G P R N A E A L A E Y V
Baker's Yeast Sacchar. cerevisiae Q12404 318 36390 R75 T F R K A A K R L D G V V Q V
Red Bread Mold Neurospora crassa Q92249 369 39263 A126 D S L S N F I A E K T G V K A
Conservation
Percent
Protein Identity: 100 N.A. 82.8 94.5 N.A. 95.4 94.7 N.A. 81.1 20.7 82.3 76.1 N.A. 21.5 59.3 55.6 47
Protein Similarity: 100 N.A. 83.4 97.5 N.A. 97.9 97.5 N.A. 86.8 38.4 92 88.8 N.A. 38.9 76.3 73.4 63.8
P-Site Identity: 100 N.A. 93.3 100 N.A. 86.6 86.6 N.A. 13.3 0 0 66.6 N.A. 20 13.3 0 6.6
P-Site Similarity: 100 N.A. 100 100 N.A. 100 100 N.A. 20 13.3 13.3 93.3 N.A. 33.3 26.6 6.6 6.6
Percent
Protein Identity: 44.3 N.A. N.A. 31.1 23.8 31.1
Protein Similarity: 63.1 N.A. N.A. 47.9 39.7 48.4
P-Site Identity: 0 N.A. N.A. 6.6 13.3 6.6
P-Site Similarity: 20 N.A. N.A. 20 13.3 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 6 12 6 0 18 0 6 6 18 6 0 6 % A
% Cys: 0 0 0 0 0 0 0 6 0 0 12 0 0 6 0 % C
% Asp: 6 6 12 0 0 36 36 6 12 53 12 6 0 6 36 % D
% Glu: 0 6 42 0 18 0 6 6 12 0 6 0 6 0 18 % E
% Phe: 0 12 6 0 6 12 6 12 36 0 6 0 0 6 6 % F
% Gly: 12 12 12 6 6 0 6 6 6 6 12 12 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 6 0 0 6 0 0 % H
% Ile: 0 18 6 6 6 0 6 0 0 0 0 0 0 0 6 % I
% Lys: 12 0 0 6 0 6 6 0 0 12 30 18 6 6 6 % K
% Leu: 6 0 6 42 0 6 0 0 12 0 6 0 0 48 6 % L
% Met: 0 0 0 0 0 0 6 0 6 0 0 6 0 0 0 % M
% Asn: 0 0 0 12 6 0 6 12 0 0 0 30 18 12 0 % N
% Pro: 0 0 0 0 6 6 6 0 6 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 6 0 % Q
% Arg: 0 0 6 0 0 6 0 6 0 0 6 0 0 0 0 % R
% Ser: 12 12 0 12 0 12 0 18 12 0 0 0 6 0 0 % S
% Thr: 12 0 0 0 36 0 6 12 0 12 6 6 0 0 0 % T
% Val: 42 24 12 6 0 12 6 0 0 0 0 6 48 6 18 % V
% Trp: 0 6 0 0 0 0 6 0 0 6 0 0 6 0 0 % W
% Tyr: 0 6 0 6 6 0 0 0 0 0 0 0 0 6 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _