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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDIA6 All Species: 29.39
Human Site: S22 Identified Species: 40.42
UniProt: Q15084 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15084 NP_005733.1 440 48121 S22 L A V N G L Y S S S D D V I E
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001095159 524 57323 S106 L A V N G L Y S S S D D V I E
Dog Lupus familis XP_532876 440 48280 S22 L A A N G L Y S S S D D V I E
Cat Felis silvestris
Mouse Mus musculus Q922R8 440 48082 S22 L A V S G L Y S S S D D V I E
Rat Rattus norvegicus Q63081 440 48155 S22 L A V S A L Y S S S D D V I E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505713 415 44653 A20 V R S A G G A A G A V P V F Q
Chicken Gallus gallus Q8JG64 505 56163 A22 V P L L A L S A G A S D V V E
Frog Xenopus laevis NP_001086643 442 47765 S22 L A A S A M Y S P S D D V I E
Zebra Danio Brachydanio rerio NP_922915 440 48022 T22 L S A Y G L Y T S S D D V V E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P54399 496 55763 V23 A A S A E A E V K V E E G V L
Honey Bee Apis mellifera XP_395981 427 47177 S21 A H C L Y S N S D V I N L K P
Nematode Worm Caenorhab. elegans Q11067 440 47710 S21 T S V C G M Y S K K D D V V E
Sea Urchin Strong. purpuratus XP_790496 399 42463 A13 V L I A V G A A S A L F D T S
Poplar Tree Populus trichocarpa XP_002320494 404 43880 K18 Q L N P S N F K S K V L N S N
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O22263 361 39478
Baker's Yeast Sacchar. cerevisiae Q12404 318 36390
Red Bread Mold Neurospora crassa Q92249 369 39263
Conservation
Percent
Protein Identity: 100 N.A. 82.8 94.5 N.A. 95.4 94.7 N.A. 81.1 20.7 82.3 76.1 N.A. 21.5 59.3 55.6 47
Protein Similarity: 100 N.A. 83.4 97.5 N.A. 97.9 97.5 N.A. 86.8 38.4 92 88.8 N.A. 38.9 76.3 73.4 63.8
P-Site Identity: 100 N.A. 100 93.3 N.A. 93.3 86.6 N.A. 13.3 26.6 66.6 66.6 N.A. 6.6 6.6 53.3 6.6
P-Site Similarity: 100 N.A. 100 93.3 N.A. 100 93.3 N.A. 40 60 80 86.6 N.A. 26.6 20 73.3 33.3
Percent
Protein Identity: 44.3 N.A. N.A. 31.1 23.8 31.1
Protein Similarity: 63.1 N.A. N.A. 47.9 39.7 48.4
P-Site Identity: 6.6 N.A. N.A. 0 0 0
P-Site Similarity: 13.3 N.A. N.A. 0 0 0
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 42 18 18 18 6 12 18 0 18 0 0 0 0 0 % A
% Cys: 0 0 6 6 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 6 0 48 53 6 0 0 % D
% Glu: 0 0 0 0 6 0 6 0 0 0 6 6 0 0 53 % E
% Phe: 0 0 0 0 0 0 6 0 0 0 0 6 0 6 0 % F
% Gly: 0 0 0 0 42 12 0 0 12 0 0 0 6 0 0 % G
% His: 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 6 0 0 0 0 0 0 0 6 0 0 36 0 % I
% Lys: 0 0 0 0 0 0 0 6 12 12 0 0 0 6 0 % K
% Leu: 42 12 6 12 0 42 0 0 0 0 6 6 6 0 6 % L
% Met: 0 0 0 0 0 12 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 6 18 0 6 6 0 0 0 0 6 6 0 6 % N
% Pro: 0 6 0 6 0 0 0 0 6 0 0 6 0 0 6 % P
% Gln: 6 0 0 0 0 0 0 0 0 0 0 0 0 0 6 % Q
% Arg: 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 12 12 18 6 6 6 48 48 42 6 0 0 6 6 % S
% Thr: 6 0 0 0 0 0 0 6 0 0 0 0 0 6 0 % T
% Val: 18 0 30 0 6 0 0 6 0 12 12 0 59 24 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 6 6 0 48 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _