KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDK1
All Species:
9.7
Human Site:
S259
Identified Species:
17.78
UniProt:
Q15118
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15118
NP_002601.1
436
49244
S259
L
E
E
L
N
A
K
S
P
G
Q
P
I
Q
V
Chimpanzee
Pan troglodytes
XP_515910
436
49246
S259
L
E
E
L
N
A
K
S
P
G
Q
P
I
Q
V
Rhesus Macaque
Macaca mulatta
XP_001086316
423
47735
S244
L
G
E
L
N
A
K
S
P
G
Q
P
I
Q
V
Dog
Lupus familis
XP_548195
458
51349
S283
E
I
N
T
A
S
N
S
K
Q
P
I
H
M
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8BFP9
434
48907
G259
E
L
N
A
K
S
P
G
Q
T
I
Q
V
V
Y
Rat
Rattus norvegicus
Q63065
434
49063
G259
E
L
N
A
K
S
P
G
Q
P
I
Q
V
V
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514685
394
44811
Q220
L
N
A
K
S
P
G
Q
P
M
Q
V
V
Y
V
Chicken
Gallus gallus
NP_001026523
408
46413
Q234
L
N
I
K
S
P
G
Q
P
M
Q
V
V
Y
V
Frog
Xenopus laevis
NP_001085016
412
46992
P236
T
E
F
N
A
K
S
P
G
Q
P
I
Q
V
V
Zebra Danio
Brachydanio rerio
XP_683576
405
46878
K231
F
N
V
K
G
P
D
K
P
V
T
V
V
Y
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P91622
413
46608
L236
S
S
E
P
G
D
N
L
P
I
R
T
V
Y
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q02332
401
45263
E227
L
E
M
H
N
A
V
E
K
G
K
P
I
S
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53170
491
57337
E280
P
M
P
E
F
I
I
E
G
D
T
Q
L
S
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
80.9
62
N.A.
91.2
92.1
N.A.
82.3
83
78.2
72.2
N.A.
51.8
N.A.
45.8
N.A.
Protein Similarity:
100
99
84.6
78.8
N.A.
94
94.5
N.A.
86.2
88.9
87.8
83
N.A.
69
N.A.
64.9
N.A.
P-Site Identity:
100
100
93.3
13.3
N.A.
0
0
N.A.
26.6
26.6
13.3
13.3
N.A.
20
N.A.
46.6
N.A.
P-Site Similarity:
100
100
93.3
20
N.A.
13.3
13.3
N.A.
40
40
13.3
20
N.A.
33.3
N.A.
60
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
41.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
16
16
31
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
8
8
0
0
8
0
0
0
0
0
% D
% Glu:
24
31
31
8
0
0
0
16
0
0
0
0
0
0
0
% E
% Phe:
8
0
8
0
8
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
8
0
0
16
0
16
16
16
31
0
0
0
0
0
% G
% His:
0
0
0
8
0
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
8
8
0
0
8
8
0
0
8
16
16
31
0
8
% I
% Lys:
0
0
0
24
16
8
24
8
16
0
8
0
0
0
0
% K
% Leu:
47
16
0
24
0
0
0
8
0
0
0
0
8
0
0
% L
% Met:
0
8
8
0
0
0
0
0
0
16
0
0
0
8
0
% M
% Asn:
0
24
24
8
31
0
16
0
0
0
0
0
0
0
0
% N
% Pro:
8
0
8
8
0
24
16
8
54
8
16
31
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
16
16
16
39
24
8
24
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% R
% Ser:
8
8
0
0
16
24
8
31
0
0
0
0
0
16
0
% S
% Thr:
8
0
0
8
0
0
0
0
0
8
16
8
0
0
0
% T
% Val:
0
0
8
0
0
0
8
0
0
8
0
24
47
24
70
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
31
16
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _