KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDK1
All Species:
22.42
Human Site:
S55
Identified Species:
41.11
UniProt:
Q15118
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15118
NP_002601.1
436
49244
S55
F
Y
A
R
F
S
P
S
P
L
S
M
K
Q
F
Chimpanzee
Pan troglodytes
XP_515910
436
49246
S55
F
Y
A
R
F
S
P
S
P
L
S
M
K
Q
F
Rhesus Macaque
Macaca mulatta
XP_001086316
423
47735
S40
R
E
D
G
N
L
S
S
G
A
H
R
A
A
P
Dog
Lupus familis
XP_548195
458
51349
S79
H
F
S
K
F
S
P
S
P
L
S
I
K
Q
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8BFP9
434
48907
S55
F
Y
A
R
F
S
P
S
P
L
S
M
K
Q
F
Rat
Rattus norvegicus
Q63065
434
49063
S55
F
Y
A
R
F
S
P
S
P
L
S
M
K
Q
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514685
394
44811
Y21
N
P
K
D
L
G
N
Y
F
I
G
S
V
N
A
Chicken
Gallus gallus
NP_001026523
408
46413
Q35
P
S
P
L
S
M
K
Q
F
L
D
F
G
S
E
Frog
Xenopus laevis
NP_001085016
412
46992
Q37
P
S
P
L
S
M
K
Q
F
L
D
F
G
S
V
Zebra Danio
Brachydanio rerio
XP_683576
405
46878
I32
P
L
S
M
K
Q
F
I
D
F
G
S
E
N
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P91622
413
46608
Q37
P
S
P
L
S
I
K
Q
F
M
D
F
G
Q
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q02332
401
45263
S28
Y
Y
S
Q
F
Q
P
S
S
L
T
I
Q
Q
Y
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53170
491
57337
N78
N
Y
L
K
R
S
P
N
P
V
S
L
T
Q
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
80.9
62
N.A.
91.2
92.1
N.A.
82.3
83
78.2
72.2
N.A.
51.8
N.A.
45.8
N.A.
Protein Similarity:
100
99
84.6
78.8
N.A.
94
94.5
N.A.
86.2
88.9
87.8
83
N.A.
69
N.A.
64.9
N.A.
P-Site Identity:
100
100
6.6
66.6
N.A.
100
100
N.A.
0
6.6
6.6
0
N.A.
6.6
N.A.
40
N.A.
P-Site Similarity:
100
100
6.6
93.3
N.A.
100
100
N.A.
6.6
6.6
6.6
13.3
N.A.
13.3
N.A.
86.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
41.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
31
0
0
0
0
0
0
8
0
0
8
8
16
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
8
0
0
0
0
8
0
24
0
0
0
0
% D
% Glu:
0
8
0
0
0
0
0
0
0
0
0
0
8
0
8
% E
% Phe:
31
8
0
0
47
0
8
0
31
8
0
24
0
0
39
% F
% Gly:
0
0
0
8
0
8
0
0
8
0
16
0
24
0
0
% G
% His:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
0
8
0
8
0
16
0
0
0
% I
% Lys:
0
0
8
16
8
0
24
0
0
0
0
0
39
0
0
% K
% Leu:
0
8
8
24
8
8
0
0
0
62
0
8
0
0
8
% L
% Met:
0
0
0
8
0
16
0
0
0
8
0
31
0
0
0
% M
% Asn:
16
0
0
0
8
0
8
8
0
0
0
0
0
16
8
% N
% Pro:
31
8
24
0
0
0
54
0
47
0
0
0
0
0
8
% P
% Gln:
0
0
0
8
0
16
0
24
0
0
0
0
8
62
0
% Q
% Arg:
8
0
0
31
8
0
0
0
0
0
0
8
0
0
0
% R
% Ser:
0
24
24
0
24
47
8
54
8
0
47
16
0
16
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
8
0
8
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
8
0
0
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
47
0
0
0
0
0
8
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _