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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDK1
All Species:
25.52
Human Site:
T431
Identified Species:
46.79
UniProt:
Q15118
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15118
NP_002601.1
436
49244
T431
S
R
E
P
K
D
M
T
T
F
R
S
A
_
_
Chimpanzee
Pan troglodytes
XP_515910
436
49246
T431
S
R
E
P
K
D
M
T
T
F
R
S
A
_
_
Rhesus Macaque
Macaca mulatta
XP_001086316
423
47735
T418
S
R
E
P
K
D
M
T
T
F
R
S
A
_
_
Dog
Lupus familis
XP_548195
458
51349
S453
S
T
E
P
K
N
T
S
T
Y
R
I
S
_
_
Cat
Felis silvestris
Mouse
Mus musculus
Q8BFP9
434
48907
T429
S
R
E
P
K
D
M
T
T
F
R
S
S
_
_
Rat
Rattus norvegicus
Q63065
434
49063
T429
S
R
E
P
K
D
M
T
T
F
R
S
S
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514685
394
44811
Chicken
Gallus gallus
NP_001026523
408
46413
Frog
Xenopus laevis
NP_001085016
412
46992
T407
S
S
E
P
K
D
M
T
T
F
R
S
N
_
_
Zebra Danio
Brachydanio rerio
XP_683576
405
46878
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P91622
413
46608
K407
V
K
Y
A
K
K
K
K
T
S
A
V
N
Q
_
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q02332
401
45263
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53170
491
57337
H482
K
L
G
N
L
M
K
H
T
K
K
L
Q
L
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
80.9
62
N.A.
91.2
92.1
N.A.
82.3
83
78.2
72.2
N.A.
51.8
N.A.
45.8
N.A.
Protein Similarity:
100
99
84.6
78.8
N.A.
94
94.5
N.A.
86.2
88.9
87.8
83
N.A.
69
N.A.
64.9
N.A.
P-Site Identity:
100
100
100
46.1
N.A.
92.3
92.3
N.A.
0
0
84.6
0
N.A.
14.2
N.A.
0
N.A.
P-Site Similarity:
100
100
100
76.9
N.A.
100
100
N.A.
0
0
84.6
0
N.A.
21.4
N.A.
0
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
41.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
0
0
0
8
0
24
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
47
0
0
0
0
0
0
0
0
8
% D
% Glu:
0
0
54
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
47
0
0
0
0
0
% F
% Gly:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% I
% Lys:
8
8
0
0
62
8
16
8
0
8
8
0
0
0
0
% K
% Leu:
0
8
0
0
8
0
0
0
0
0
0
8
0
8
0
% L
% Met:
0
0
0
0
0
8
47
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
8
0
0
0
0
0
0
16
0
0
% N
% Pro:
0
0
0
54
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
0
% Q
% Arg:
0
39
0
0
0
0
0
0
0
0
54
0
0
0
0
% R
% Ser:
54
8
0
0
0
0
0
8
0
8
0
47
24
0
0
% S
% Thr:
0
8
0
0
0
0
8
47
70
0
0
0
0
0
0
% T
% Val:
8
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
54
62
% _