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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDK1
All Species:
23.64
Human Site:
Y136
Identified Species:
43.33
UniProt:
Q15118
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15118
NP_002601.1
436
49244
Y136
A
E
D
A
K
A
I
Y
D
F
T
D
T
V
I
Chimpanzee
Pan troglodytes
XP_515910
436
49246
Y136
A
E
D
A
K
A
I
Y
D
F
T
D
T
V
I
Rhesus Macaque
Macaca mulatta
XP_001086316
423
47735
Y121
A
E
D
A
K
A
I
Y
D
F
T
D
T
V
I
Dog
Lupus familis
XP_548195
458
51349
S160
P
E
D
H
R
T
L
S
Q
F
T
D
A
L
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8BFP9
434
48907
Y136
A
E
D
A
K
T
I
Y
E
F
T
D
T
V
I
Rat
Rattus norvegicus
Q63065
434
49063
Y136
A
E
D
A
K
T
I
Y
E
F
T
D
T
V
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514685
394
44811
T97
S
K
T
I
Y
D
F
T
D
T
V
I
T
I
R
Chicken
Gallus gallus
NP_001026523
408
46413
S111
E
D
S
G
A
I
H
S
F
T
D
T
V
I
K
Frog
Xenopus laevis
NP_001085016
412
46992
K113
E
D
L
N
T
V
Q
K
F
T
D
T
V
I
T
Zebra Danio
Brachydanio rerio
XP_683576
405
46878
T108
E
T
V
N
H
D
F
T
D
A
V
I
K
I
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P91622
413
46608
V113
H
D
N
L
Q
K
F
V
A
D
L
D
L
I
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q02332
401
45263
E104
E
A
S
D
S
S
P
E
Q
V
A
R
F
N
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53170
491
57337
T157
R
K
Y
P
T
I
R
T
L
E
D
A
S
Q
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
80.9
62
N.A.
91.2
92.1
N.A.
82.3
83
78.2
72.2
N.A.
51.8
N.A.
45.8
N.A.
Protein Similarity:
100
99
84.6
78.8
N.A.
94
94.5
N.A.
86.2
88.9
87.8
83
N.A.
69
N.A.
64.9
N.A.
P-Site Identity:
100
100
100
33.3
N.A.
86.6
86.6
N.A.
13.3
0
0
6.6
N.A.
6.6
N.A.
0
N.A.
P-Site Similarity:
100
100
100
60
N.A.
93.3
93.3
N.A.
33.3
13.3
13.3
13.3
N.A.
33.3
N.A.
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
41.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
39
8
0
39
8
24
0
0
8
8
8
8
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
24
47
8
0
16
0
0
39
8
24
54
0
0
8
% D
% Glu:
31
47
0
0
0
0
0
8
16
8
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
24
0
16
47
0
0
8
0
8
% F
% Gly:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
8
0
0
8
8
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
0
16
39
0
0
0
0
16
0
39
39
% I
% Lys:
0
16
0
0
39
8
0
8
0
0
0
0
8
0
8
% K
% Leu:
0
0
8
8
0
0
8
0
8
0
8
0
8
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
16
0
0
0
0
0
0
0
0
0
8
0
% N
% Pro:
8
0
0
8
0
0
8
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
8
0
8
0
16
0
0
0
0
8
0
% Q
% Arg:
8
0
0
0
8
0
8
0
0
0
0
8
0
0
24
% R
% Ser:
8
0
16
0
8
8
0
16
0
0
0
0
8
0
0
% S
% Thr:
0
8
8
0
16
24
0
24
0
24
47
16
47
0
8
% T
% Val:
0
0
8
0
0
8
0
8
0
8
16
0
16
39
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
8
0
0
39
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _