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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDK1
All Species:
25.45
Human Site:
Y334
Identified Species:
46.67
UniProt:
Q15118
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15118
NP_002601.1
436
49244
Y334
K
I
D
R
L
F
N
Y
M
Y
S
T
A
P
R
Chimpanzee
Pan troglodytes
XP_515910
436
49246
Y334
K
I
D
R
L
F
N
Y
M
Y
S
T
A
P
R
Rhesus Macaque
Macaca mulatta
XP_001086316
423
47735
Y321
D
R
L
F
N
Y
M
Y
S
T
A
P
R
P
R
Dog
Lupus familis
XP_548195
458
51349
S356
R
K
I
E
R
L
F
S
Y
M
Y
S
T
A
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8BFP9
434
48907
Y332
K
I
D
R
L
F
N
Y
M
Y
S
T
A
P
R
Rat
Rattus norvegicus
Q63065
434
49063
Y332
K
I
D
R
L
F
N
Y
M
Y
S
T
A
P
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514685
394
44811
M293
I
D
R
L
F
N
Y
M
Y
S
T
A
P
R
P
Chicken
Gallus gallus
NP_001026523
408
46413
M307
I
D
R
L
F
N
Y
M
Y
S
T
A
P
R
P
Frog
Xenopus laevis
NP_001085016
412
46992
Y310
K
I
E
R
L
F
N
Y
M
Y
S
T
A
P
L
Zebra Danio
Brachydanio rerio
XP_683576
405
46878
T304
I
D
R
L
F
T
Y
T
Y
S
T
A
P
R
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P91622
413
46608
Y310
Q
T
D
Q
L
F
K
Y
M
Y
S
T
A
P
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q02332
401
45263
Y300
R
T
I
L
E
R
L
Y
N
Y
M
Y
S
T
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53170
491
57337
V385
T
V
S
I
Y
D
E
V
H
S
H
T
K
Y
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
80.9
62
N.A.
91.2
92.1
N.A.
82.3
83
78.2
72.2
N.A.
51.8
N.A.
45.8
N.A.
Protein Similarity:
100
99
84.6
78.8
N.A.
94
94.5
N.A.
86.2
88.9
87.8
83
N.A.
69
N.A.
64.9
N.A.
P-Site Identity:
100
100
20
0
N.A.
100
100
N.A.
0
0
86.6
0
N.A.
66.6
N.A.
13.3
N.A.
P-Site Similarity:
100
100
33.3
13.3
N.A.
100
100
N.A.
6.6
6.6
93.3
6.6
N.A.
86.6
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
41.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
8
24
47
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
24
39
0
0
8
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
8
8
8
0
8
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
8
24
47
8
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
8
0
0
0
0
% H
% Ile:
24
39
16
8
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
39
8
0
0
0
0
8
0
0
0
0
0
8
0
0
% K
% Leu:
0
0
8
31
47
8
8
0
0
0
0
0
0
0
8
% L
% Met:
0
0
0
0
0
0
8
16
47
8
8
0
0
0
0
% M
% Asn:
0
0
0
0
8
16
39
0
8
0
0
0
0
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
8
24
54
31
% P
% Gln:
8
0
0
8
0
0
0
0
0
0
0
0
0
0
8
% Q
% Arg:
16
8
24
39
8
8
0
0
0
0
0
0
8
24
39
% R
% Ser:
0
0
8
0
0
0
0
8
8
31
47
8
8
0
0
% S
% Thr:
8
16
0
0
0
8
0
8
0
8
24
54
8
8
0
% T
% Val:
0
8
0
0
0
0
0
8
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
8
24
62
31
54
8
8
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _