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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDK2
All Species:
31.52
Human Site:
S289
Identified Species:
69.33
UniProt:
Q15119
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15119
NP_002602.2
407
46154
S289
E
D
L
S
I
K
M
S
D
R
G
G
G
V
P
Chimpanzee
Pan troglodytes
XP_523791
407
46204
S289
E
D
L
S
I
K
M
S
D
R
G
G
G
V
P
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_548195
458
51349
S340
E
D
L
S
I
K
M
S
D
R
G
G
G
V
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9JK42
407
46050
S289
E
D
L
S
I
K
M
S
D
R
G
G
G
V
P
Rat
Rattus norvegicus
Q64536
407
46087
S289
E
D
L
S
I
K
M
S
D
R
G
G
G
V
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026523
408
46413
S289
E
D
L
T
V
K
M
S
D
R
G
G
G
V
P
Frog
Xenopus laevis
NP_001083278
404
46003
K287
G
N
E
D
V
T
I
K
I
S
D
N
G
G
G
Zebra Danio
Brachydanio rerio
XP_001332594
409
46623
S289
E
D
L
T
I
K
M
S
D
R
G
G
G
V
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P91622
413
46608
S293
E
D
I
C
V
K
I
S
D
Q
G
G
G
I
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q02332
401
45263
C285
E
D
L
S
I
K
I
C
D
R
G
G
G
V
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40530
394
45425
A275
V
F
K
N
A
F
E
A
Q
I
A
L
G
K
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
N.A.
87.9
N.A.
97.3
97.5
N.A.
N.A.
68.8
74.6
73.1
N.A.
54.2
N.A.
48.8
N.A.
Protein Similarity:
100
99.7
N.A.
88.8
N.A.
98.7
98.7
N.A.
N.A.
84.5
87.2
86.8
N.A.
71.1
N.A.
66.3
N.A.
P-Site Identity:
100
100
N.A.
100
N.A.
100
100
N.A.
N.A.
86.6
6.6
93.3
N.A.
60
N.A.
80
N.A.
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
N.A.
100
26.6
100
N.A.
93.3
N.A.
86.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
43
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
0
0
10
0
0
10
0
0
0
0
% A
% Cys:
0
0
0
10
0
0
0
10
0
0
0
0
0
0
0
% C
% Asp:
0
82
0
10
0
0
0
0
82
0
10
0
0
0
0
% D
% Glu:
82
0
10
0
0
0
10
0
0
0
0
0
0
0
10
% E
% Phe:
0
10
0
0
0
10
0
0
0
0
0
0
0
0
0
% F
% Gly:
10
0
0
0
0
0
0
0
0
0
82
82
100
10
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
0
64
0
28
0
10
10
0
0
0
10
0
% I
% Lys:
0
0
10
0
0
82
0
10
0
0
0
0
0
10
0
% K
% Leu:
0
0
73
0
0
0
0
0
0
0
0
10
0
0
0
% L
% Met:
0
0
0
0
0
0
64
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
10
0
0
0
0
0
0
0
10
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
73
% P
% Gln:
0
0
0
0
0
0
0
0
10
10
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
73
0
0
0
0
0
% R
% Ser:
0
0
0
55
0
0
0
73
0
10
0
0
0
0
10
% S
% Thr:
0
0
0
19
0
10
0
0
0
0
0
0
0
0
0
% T
% Val:
10
0
0
0
28
0
0
0
0
0
0
0
0
73
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _